Relationship Between Recurrence Season and Prognosis in Patients with Advanced Invasive Breast Cancer Based on the Concept of Normal Movement of the Heavens Depending on the Normal Shining of the Sun
Objective To explore the impact of the season of recurrence on the prognosis of patients with ad-vanced invasive breast cancer based on the theory of normal movement of the heavens depending on the normal shining of the sun.Methods Clinical data of 78 patients with advanced invasive breast cancer treated between January 2012 and January 2022 were selected from the Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine and the Ethnomedicine Hospital of Guangxi Medical University.The patients were divided into an observation group(48 patients from the Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine)and a control group(30 patients from the Ethnomedicine Hospital of Guangxi Medical University).In the first step,patients in both groups were categorized into spring-summer and autumn-winter groups based on the season of cancer recurrence.In the second step,the groups were further subdivided as follows:the observation group into spring,summer,and autumn-winter groups,and the control group into spring-summer,autumn,and winter groups.Prognostic outcomes included survival time from the first recurrence to death,overall survival,and progression-free survival.Cox univariate and multivariate regression analysis,as well as survival analysis,were used to explore the factors influencing adverse prognosis and the relationship between the season of recurrence and prognosis.Results Traditional Chinese medicine(TCM)syndromes and the initial site of metastasis were independent risk factors affecting the prognosis of patients with advanced breast cancer in the observation group.In the observation group,the median overall survival was 55 months for patients who recurred in spring-summer and 18 months for those who recurred in autumn-winter.The survival advantage and overall survival time after recurrence were significantly superior for patients who recurred in spring-summer to those who recurred in autumn-winter(P<0.01).Both progression survival and overall survival for patients who recurred in spring-summer and autumn were superior to those who recurred in winter(P<0.01).In the control group,progression survival for patients who recurred in spring-summer and autumn was supe-rior to those who recurred in winter(P<0.05).Conclusion The season of recurrence has a certain impact on the surviv-al time of patients with advanced invasive breast cancer.
Invasive Breast CancerMetastasisSeasonPrognosisSurvival Analysis