Clinical Efficacy of Bushen Jianpi Qushi Tongluo Therapies in Treatment of Gout Patients
Objective To observe the efficacy of Bushen Jianpi Qushi Tongluo therapies(kidneys-tonifying,spleen-strengthening,dampness-removing,and collaterals-dredging therapies)in the treatment of gout patients and its regulatory effects on inflammation and metabolic indicators.Methods A total of 132 gout patients treated at the Hei-longjiang Academy of Chinese Medicine Sciences from February 2021 to February 2023 were selected and randomly divided into a control group and an observation group according to a random number table,with 66 patients in each group.The control group received conventional drug treatment,while the observation group received Bushen Jianpi Qushi Tongluo therapies in addition to the conventional treatment for a duration of 4 weeks.The traditional Chinese medicine(TCM)syndrome scores and local joint scores were evaluated before and after treatment.The treatment effects of both groups were compared,and serum uric acid(SUA),erythrocyte sedimentation rate(ESR),serum hypersensitive C-reactive protein(hs-CRP),inter-leukin-1β(IL-1β),interleukin-6(IL-6),interleukin-18(IL-18),tumor necrosis factor-α(TNF-α),and lipid metabolism indicators[triglycerides(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),and high-density lipoprotein cholesterol(HDL-C)]were measured.Results After treatment,the scores for joint pain,difficulty in flexion and extension,soreness and weakness in the waist and knees,fatigue,heaviness in the limbs,generalized edema,scores of concomitant symptoms,and total scores in both groups were significantly lower than those before treatment(P＜0.05).The TCM syndrome scores in the observation group were significantly lower than those in the control group(P＜0.05).The scores for joint pain,joint tenderness,joint redness and swelling,and mobility impairment were significantly lower in both groups after treatment(P＜0.05),with the observation group showing lower local joint scores than the control group(P＜0.05).The levels of SUA and ESR in both groups decreased significantly after treatment(P＜0.05),and the levels in the observation group were lower than those in the control group(P＜0.05).The levels of hs-CRP,IL-1β,IL-6,IL-18,and TNF-α in both groups significantly decreased after treatment(P＜0.05),with the observation group showing lower serum inflammatory factor levels than the control group(P＜0.05).TC,TG,and LDL-C levels in both groups decreased significantly after treatment,with the observation group showing lower levels than the control group(P＜0.05).There was no significant change in HDL-C levels in the control group after treatment(P＞0.05),whereas HDL-C levels in the observation group increased significantly and were higher than those in the control group(P＜0.05).There was no statistically significant difference in the overall clinical efficacy rate between the two groups(x2=2.948,P=0.086).However,the cure and improvement rate in the observation group was 81.82％(54/66),significantly higher than 62.12％(41/66)in the control group(x2=8.667,P=0.003).The incidence of adverse reactions during treatment did not differ significantly between the two groups(P＞0.05).Conclusion Bushen Jianpi Qushi Tongluo therapies can im-prove the efficacy of gout treatment and lower SUA levels,potentially through the regulation of inflammatory responses and metabolic abnormalities.
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