Clinical Efficacy of Simiao Yong'an Decoction with Negative Pressure Drip Irriga-tion in Treatment of Patients with Damp-Heat Intrinsic Diabetic Foot Accompanied by Critical Lower Limb Ischemia
Objective To investigate the clinical efficacy of Simiao Yong'an decoction with negative pressure drip irrigation in treating patients with damp-heat intrinsic diabetic foot(DF)accompanied by critical lower limb ischemia(CLI).Methods A total of 60 patients with diabetic foot accompanied by critical lower limb ischemia,treated at The Second Affiliated Hospital of Xingtai Medical College between June 2021 and October 2023 were selected.They were divid-ed into a control group and an observation according to the random number table method,with 30 patients in each group.Preoperative WIFI classification was performed,and appropriate endovascular treatments were applied.After successful re-vascularization,open amputation or debridement of gangrenous toes or toe rows was performed.The control group received negative pressure closed drainage(VSD)postoperatively,while the observation group received Simiao Yong'an decoction via negative pressure drip irrigation.One week post-treatment,the VSD dressing was removed to assess the wound.Wound re-pair was performed after negative bacterial culture results were confirmed until the wound healed.Serum C-reactive pro-tein(CRP)and procalcitonin(PCT)levels were measured after 1 and 2 weeks of treatment.The bacterial conversion rate of the wound,transcutaneous oxygen pressure(TcPO2),ankle-brachial index(ABI),wound healing time,and adverse reac-tions were also assessed after 2 weeks of treatment.Results The overall efficacy rate in the observation group(90%,27/30)was significantly higher than that in the control group(80%,24/30),with a statistically significant difference(P<0.05).After treatment,CRP and PCT levels in both groups were significantly lower than before treatment,with statistically significant differences(P<0.05);the CRP and PCT levels in the observation group were significantly lower than those in the control group,with statistically significant differences(P<0.05).The negative bacterial culture conversion rate of the wound in the observation group(90%,27/30)was significantly higher than that in the control group(70%,21/30),with a statistically significant difference(P<0.05).TcPO2 levels increased significantly in both groups after treatment,with a sta-tistically significant difference(P<0.05);the levels in the observation group were significantly higher than those in the control group,with a statistically significant difference(P<0.05).No significant difference was found between the two groups in ABI before and after treatment(P>0.05).The wound healing time in the observation group(28.63±5.30 days)was significantly shorter than in the control group(40.87±5.14 days),with a statistically significant difference(P<0.05).During the treatment period,no adverse reactions such as allergies,swelling,or aggravated infection occurred in either group.Conclusion Simiao Yong'an decoction with negative pressure drip irrigation is effective in controlling infec-tion,improving local microcirculation,and reducing wound healing time in diabetic foot(DF)patients with critical lower limb ischemia(CLI)of damp-heat intrinsic type after endovascular treatment.This approach has significant clinical appli-cation and promotion value.