Exploring the Efficacy of Chaiqin Magao Decoction Combined with Xuebijing Injec-tion in Treating Severe Pneumonia Patients Based on the Theory of Simultaneous Treatment of Lung and Intestine
Objective To investigate the clinical efficacy of Chaiqin Magao decoction combined with Xuebijing injection in treating patients with severe pneumonia.Methods A total of 70 patients with severe pneumonia combined with type Ⅱ respiratory failure admitted to Zhengzhou Central Hospital Affiliated to Zhengzhou University from January 2019 to January 2022 were selected as the study subjects.They were divided into a control group and a study group using the random number table method,with 35 patients in each group.The control group was given conventional treatment,while the study group was given Chaiqin Magao decoction combined with Xuebijing injection based on the control group.Both groups were treated for 7 days.The clinical efficacy,incidence of adverse reactions,and traditional Chinese medicine(TCM)syndrome scores,Acute Physiology and Chronic Health Evaluation Ⅱ(APACHE Ⅱ)scores,serum markers[diam-ine oxidase(DAO),D-lactic acid(D-LA),tumor necrosis factor-α(TNF-α),procalcitonin(PCT)and interleukin-6(IL-6)],and lung function indicators[first-second forced expiratory volume(FEV1),peak expiratory flow(PEF),forced vital capacity(FVC)]were observed and compared between the two groups before and after treatment.Results After treatment,the total clinical effective rate was significantly higher in the study group(91.43％,32/35)than in the control group(71.43％,25/35),with a statistically significant difference(P＜0.05).TCM syndrome scores and APACHE Ⅱscores in both groups were significantly lower after treatment compared to before treatment,with a statistically significant difference(P＜0.05);these scores were significantly lower in the study group than in the control group,with a statistically significant difference(P＜0.05).DAO,D-LA,TNF-α,PCT and IL-6 levels in both groups were significantly lower af-ter treatment compared to before treatment,with a statistically significant difference(P＜0.05);these serum markers were significantly lower in the study group than in the control group,with a statistically significant difference(P＜0.05).FVC,FEV1,and PEF levels in both groups were significantly higher after treatment compared to before treatment,with a statisti-cally significant difference(P＜0.05);these lung function indicators were significantly higher in the study group than in the control group,with a statistically significant difference(P＜0.05).During the treatment period,there was no significant difference in the incidence of adverse reactions between the two groups,without a statistically significant difference(P＞0.05).Conclusion Chaiqin Magao decoction combined with Xuebijing injection,based on the theory of simultaneous treatment of lung and intestines,can effectively treat severe pneumonia,improve symptoms and disease conditions,reduce the inflammatory reaction,and protect intestinal mucosal barrier function,with reliable safety.
Theory of Simultaneous Treatment of Lung and IntestineChaiqin Magao DecoctionXuebijing Injec-tionSevere Pneumonia
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