Correlation Study Between Prehypertensive Liver-Fire Hyperactivity Syndrome and Plasma Homocysteine
Objective To investigate the correlation between prehypertensive liver-fire hyperactivity syndrome and homocysteine and its assay indexes.Methods From November 2016 to November 2019,84 patients diagnosed with prehypertensive liver-fire hyperactivity syndrome were selected from the Department of Cardiology and Health Examina-tion Center at the Affiliated Hospital of Shandong University of Traditional Chinese Medicine.Meanwhile,53 patients with ideal blood pressure and 52 patients with hypertensive liver-fire hyperactivity syndrome were treated during the same peri-od.Subjects underwent general examinations(height,weight,blood pressure,resting heart rate),and tests for plasma homo-cysteine(Hey),biochemical indicators,and urinary microalbumin levels.Results The detection rate of serum hyperhomo-cysteine(HHcy)in the prehypertensive liver-fire hyperactivity syndrome group was 7.14％,while the detection rate of HHcy in the hypertensive liver-fire hyperactivity syndrome group was 76.92％,showing an increasing trend.The positive detection rate of urinary microalbumin in the prehypertensive liver-fire hyperactivity syndrome group was 1.92％and 10.81％in the hypertensive liver-fire hyperactivity syndrome group,showing an increasing trend.LSD-t test results showed statistically significant differences in Hey levels between the ideal blood pressure group and both the hypertensive liver-fire hyperactivity syndrome group and the prehypertensive liver-fire hyperactivity syndrome group,with a statistically significant difference(P＜0.05).There were also significant differences in total cholesterol and low-density lipoprotein cho-lesterol(LDL-C)levels between the ideal blood pressure group and the prehypertensive liver-fire hyperactivity syndrome group,with a statistically significant difference(P＜0.05).Pearson correlation analysis of homocysteine levels in the pre-hypertensive liver-fire hyperactivity syndrome group showed that homocysteine correlated with serum uric acid and serum creatinine(P＜0.05).Conclusion Homocysteine levels are elevated in patients with prehypertensive liver-fire hyperac-tivity syndrome,and homocysteine is associated with serum uric acid and serum creatinine levels.
万方数据
维普
