Therapeutic Effect of Shugan Jianpi Formula Combined with Flupentixol-Melitra-cen Tablets on Depression after Breast Cancer
Objective To observe the therapeutic effect of Shugan Jianpi Formula combined with flupentixol-melitracen tablets on depression after breast cancer.Methods Eighty patients with depression after breast cancer treated in the Tangshan Traditional Chinese Medicine Hospital from June 2020 to June 2022 were selected and assigned with the random number table method into a control group and an observation group,with 40 patients in each group.The control group was treated with flupentixol-melitracen tablets,while the observation group was treated with Shugan Jianpi Formula on the basis of the therapy in the control group.Both groups were treated for 8 weeks.The therapeutic effect and the inci-dence of adverse reactions,depression emotion,and sleep disorders were compared between the two groups.The traditional Chinese medicine(TCM)symptom scores,Hamilton Depression Scale(HAMD)score,Self-Rating Anxiety Scale(SAS)score,Pittsburgh Sleep Quality Index(PSQI),and levels of neurotransmitters[5-hydroxytryptamine(5-HT),norepineph-rine(NE),and dopamine(DA)]were measured before and after treatment.Results After treatment,the scores of low mood,worry and suspicion,overthinking,fatigue,HAMD,SAS,and PSQI in both groups declined(P＜0.05),and the observation group had lower scores than the control group(P＜0.05).After treatment,the levels of 5-HT,NE,and DA in both groups rose(P＜0.05),and the observation group had higher levels of 5-HT,NE,and DA than the control group(P＜0.05).The total response rate in the observation group was 92.50％(37/40),which was higher than that(75.00％,30/40)in the control group(P＜0.05).The incidence of depression emotion and sleep disorders in the control group was 10.00％(4/40)and 15.00％(6/40),respectively,which had no significant difference compared with that[2.50％(1/40)and 5.00％(2/40)]in the observation group(P＞0.05).The incidence of adverse reactions showed no significant difference between the two groups during the treatment period(P＞0.05).Conclusion Shugan Jianpi Formula combined with flupentixol-melitracen tablets can promote the secretion of neurotransmitters,alleviate depression,and improve sleep quality in the pa-tients with depression after breast cancer(syndrome of liver depression and spleen deficiency),demonstrating definite ther-apeutic effect and high safety.
Breast CancerDepressionShugan Jianpi FormulaFlupentixol-Melitracen TabletsSyndrome of Liv-er Depression and Spleen DeficiencyNeurotransmitters
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