Efficacy of Sangqi Ziyin Bushen Decoction in Treating Hypertensive Patients with Carotid Atherosclerosis Characterized by Yin Deficiency and Yang Hyperactivity Syndrome,and Its Effects on Serum Inflammatory Factors and Vascular Endothelial Function
Objective To study the clinical efficacy of Sangqi Ziyin Bushen decoction as an adjunct therapy for hypertensive patients with carotid arteriosclerosis characterized by Yin deficiency and Yang hyperactivity syndrome,and its effects on serum inflammatory factors and vascular endothelial function.Methods 96 hypertensive patients with carotid atherosclerosis of the Yin deficiency and Yang hyperactivity type were admitted at The Eighth People's Hospital of Hefei between July 2019 and December 2021.They were selected and randomly divided into a control group and a treatment group,with 48 cases in each group.The control group received a combination of atorvastatin and levamlodipine besylate,while the treatment group received Sangqi Ziyin Bushen decoction in addition to the control group's treatment.After 3 months of treatment,clinical efficacy was observed and compared between the two groups.Traditional Chinese medicine(TCM)syndrome scores,serum inflammatory factors[hypersensitive C-reactive protein(hs-CRP),interleukin-6(IL-6),interleukin-10(IL-10),tumor necrosis factor-α(TNF-α)],vascular endothelial function[endothelin-1(ET-1),nitric oxide(NO),thromboxane B2(TXB2),angiotensin Ⅱ(AngⅡ)],blood pressure and lipids levels[systolic blood pressure(SBP),diastolic blood pressure(DBP),triglycerides(TG),total cholesterol(TC),low-density lipoprotein cho-lesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C)],and plaque-related indexes[carotid intima-media thickness(IMT),plaque area,plaque number]were assessed before and after treatment.Results After treatment,scores for dizziness,headache,lower back,and knee softness,five heart fever,palpitations,insomnia,tinnitus,forgetfulness,as well as total TCM syndrome scores,were all significantly reduced in both groups compared before treatment levels,with statistically significant differences(P＜0.05);the treatment group showed significantly lower scores in these symptoms and total TCM syndrome scores compared to the control group,with statistically significant differences(P＜0.05).Serum levels of hs-CRP,IL-6,and TNF-α significantly decreased,and IL-10 levels significantly increased in both groups after treatment,with statistically significant differences(P＜0.05);the treatment group had significantly lower levels of hs-CRP,IL-6,and TNF-α,and significantly higher IL-10 levels compared to the control group,with statistically signifi-cant differences(P＜0.05).Serum NO levels significantly increased,while ET-1,AngⅡ,and TXB2 levels significantly decreased in both groups after treatment,with statistically significant differences(P＜0.05);the treatment group had sig-nificantly higher NO levels and lower ET-1,Ang Ⅱ,TXB2 levels than the control group,with statistically significant differ-ences(P＜0.05).SBP,DBP,TG,TC,and LDL-C levels were significantly reduced after treatment,and HDL-C levels significantly increased in both groups,with statistically significant differences(P＜0.05);the treatment group showed sig-nificantly lower SBP,DBP,TG,TC,and LDL-C levels,and higher HDL-C levels compared to the control group,with sta-tistically significant differences(P＜0.05).IMT,plaque area,and plaque number significantly decreased in both groups af-ter treatment,with statistically significant differences(P＜0.05);the treatment group showed significantly lower values in these indexes compared to the control group,with statistically significant differences(P＜0.05).The total clinical efficacy rate in the treatment group was 93.48％(43/46),which was significantly higher than the 77.27％(34/44)in the control group,with a statistically significant difference(x2=4.601,P=0.032＜0.05).Conclusion Sangqi Ziyin Bushen decoc-tion as an adjuvant therapy can significantly alleviate clinical symptoms in hypertensive patients with carotid arteriosclerosis characterized by Yin deficiency and Yang hyperactivity syndrome.It helps control blood pressure and lipid levels and re-verse the progression of carotid arteriosclerosis.This effect may related to its anti-inflammatory properties and its ability to improve vascular endothelial function.
HypertensionCarotid AtherosclerosisYin Deficiency and Yang HyperactivitySangqi Ziyin Bushen DecoctionInflammatory FactorsVascular Endothelial Function
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