Efficacy of Staged Traditional Chinese Medicine Treatment in Patients with Chronic Atrophic Gastritis of Spleen-stomach Damp-Heat Type Accompanied by Low-Grade Intraepithelial Neoplasia
Objective To investigate the clinical efficacy of staged traditional Chinese medicine(TCM)treatment in patients with chronic atrophic gastritis(C AG)of the spleen-stomach damp-heat type accompanied by low-grade gas-tric intraepithelial neoplasia(LGIN).Methods From March 2021 to May 2023,120 patients with CAG of the spleen-stomach damp-heat type accompanied by LGIN,administered at Hebei Provincial Hospital of Traditional Chinese Medi-cine,were selected as the research subjects.The patients were randomly divided into a control group and a study group ac-cording to the random number table method,with 60 patients in each group.The control group was treated with conventional treatment for CAG with LGIN,while the study group was treated with the Qingre Huashi Tongluo formula for 4 weeks,fol-lowed by the Jianpi Yiqi Hewei Huashi formula for another 4 weeks.Both groups were treated for a total of 8 weeks.TCM symptom scores,gastric mucosal pathology scores,serum levels of pepsinogen Ⅰ(PG Ⅰ),pepsinogen Ⅱ(PG Ⅱ),the PGⅠ/PG Ⅱ ratio,serum inflammatory cytokines[Interleukin-6(IL-6),Interleukin-8(IL-8),Interleukin-10(IL-10),tumor necrosis factor-α(TNF-α)],serum tumor markers[carcinoembryonic antigen(CEA),carbohydrate antigen 724(CA724),carbohydrate antigen 199(CA199),carbohydrate antigen 125(CA125)],immune function indicators[Immuno-globulin A(IgA),Immunoglobulin M(IgM),Immunoglobulin G(IgG),Interleukin-2(IL-2),Interferon-y(IFN-y),inhibitory T cells(CD8+),mature T lymphocytes(CD3+),induced T cells(CD4+),CD4+/CD8+ratio],clinical efficacy and adverse reactions were observed and compared before and after treatment.Results After treatment,the total clinical efficacy rate in the study group was 96.67%(58/60),significantly higher than the 85.00%(51/60)in the control group,with a statistically significant difference(P<0.05).After treatment,TCM symptom scores and total scores in both groups significantly decreased compared to before treatment,with statistically significant differences(P<0.05);the study group showed significantly lower scores than the control group,with statistically significant differences(P<0.05).The pathologi-cal scores of gastric mucosal also decreased significantly in both groups after treatment,with a statistically significant differ-ence(P<0.05);the study group showed significantly lower scores than the control group,with a statistically significant difference(P<0.05).Additionally,the levels of PGⅠ,PG Ⅱ,and the PGⅠ/PG Ⅱ ratio increased significantly in both groups after treatment,with statistically significant differences(P<0.05);the study group showed significantly higher levels com-pared to the control group,with statistically significant differences(P<0.05).Serum levels of TNF-α,IL-8,IL-6,and IL-10 decreased significantly in both groups,with statistically significant differences(P<0.05);the study group showed significantly lower levels compared to the control group,with statistically significant differences(P<0.05).Tumor markers CA199,CEA,CA724,and CA125 also significantly decreased in both groups after treatment,with statistically significant differences(P<0.05);the study group showed significantly lower levels than the control group,with statistically significant differences(P<0.05).Immune function indicators(CD3+,CD4+,CD4+/CD8+,IgA,IgM,IgG,IL-2,and IFN-γ)in-creased significantly in both groups after treatment,while CD8+levels decreased,with statistically significant differences(P<0.05).The study group had significantly higher levels of CD3+,CD4+,CD4+/CD8+,IgA,IgM,IgG,IL-2,and IFN-γ,and significantly lower CD8+levels compared to the control group,with statistically significant differences(P<0.05).During the treatment period,there was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Staged TCM treatment for spleen-stomach damp-heat type CAG with LGIN is highly effective.It alleviates clinical symptoms,reduces gastric mucosal damage,inhibits inflammatory responses,enhances immune function,blocks disease progression,and lowers the risk of gastric cancer.