首页|基于数据挖掘探析孙丽蕴教授治疗风湿蕴肤型扁平苔癣的用药规律

基于数据挖掘探析孙丽蕴教授治疗风湿蕴肤型扁平苔癣的用药规律

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目的 通过中医传承辅助平台挖掘探讨孙丽蕴教授治疗风湿蕴肤型扁平苔癣(Lichen planus,LP)的用药组方规律.方法 收集和整理2019年2月—2023年10月期间孙丽蕴教授门诊诊治风湿蕴肤型LP的医案,并进行标准化录入,运用关联规则分析、复杂系统熵聚类分析等方法对药物进行分析.结果 71例风湿蕴肤型LP患者男女性别比例为1∶1.3,平均年龄(49.65±16.60)岁.(1)频次≥30的药物共32味,依次为钩藤、鸡血藤、徐长卿等;(2)药物性味多性寒、味苦,归肝、胃经为主;(3)复杂系统熵聚类分析:高频药对19个,包括"鸡血藤-钩藤"等组合;包括"香橼-苏木-三棱"等26个核心药物组合;香橼-苏木-三棱-路路通-石菖蒲等13个新处方.结论 孙丽蕴教授认为风湿蕴肤型LP的主要病因病机以阴阳失调为本,风、湿、热、瘀、毒邪互结为标,在治疗过程中,以调和阴阳,祛风利湿,清热活血为主,兼顾养护脾胃,调畅情志,为LP的临床遣方用药和新药开发提供一定参考.
Medication Rules of Professor Sun Liyun in Treatment of Lichen Planus with Wind-Dampness Accumulation in the Skin Syndrome Based on Data Mining
Objective To explore and analyze the prescription patterns of Professor Sun Liyun in treating lichen planus(LP)with wind-dampness accumulation in the skin syndrome through the Traditional Chinese Medicine Inheritance Support Platform.Methods Medical records of Professor Sun Liyun's outpatient treatment of LP with wind-dampness ac-cumulation in the skin syndrome from February 2019 to October 2023 were collected and organized,followed by standard-ized input.The data were then analyzed using association rule analysis and complex system entropy clustering analysis.Re-sults A total of 71 LP patients with wind-dampness accumulation in the skin syndrome were included,with a male-to-female ratio of 1∶1.3 and a mean age of(49.65±16.60)years.(1)A total of 32 drugs were used with a frequency of≥30,including Uncariae Ramulus cum Uncis,Spatholobi Caulis,and Cynanchi Paniculati Radix et Rhizoma.(2)The drugs were mostly cold in nature and bitter in flavor,primarily acting on the liver and stomach meridians.(3)Complex system en-tropy clustering analysis identified 19 high-frequency drug pairs,including combinations such as Spatholobi Caulis-Un-cariae Ramulus cum Uncis,26 core drug combinations such as Citri Fructus-Sappan Lignum-Sparganii Rhizoma,and 13 new prescriptions including Citri Fructus-Sappan Lignum-Sparganii Rhizoma-Liquidambaris Fructus-Acori Tatari-nowii Rhizoma.Conclusion Professor Sun Liyun believes that the main pathogenesis of LP with wind-dampness accu-mulation in the skin is rooted in yin-yang imbalance,with wind,dampness,heat,stasis,and toxins as manifestations.The treatment focuses on regulating yin and yang,dispelling wind and dampness,clearing heat,and activating blood circulation,while also considering the nourishment of the spleen and stomach and regulating emotions.This approach provides a refer-ence for the clinical prescription of LP and the development of new medications.

Lichen PlanusTraditional Chinese Medicine Inheritance Support SystemData MiningAnalysis of Medication Experience

房玲、刘晔、杨惠卿、孙丽蕴

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北京市大兴区人民医院中医科,北京 102600

首都医科大学附属北京中医医院皮肤科,北京 100010

扁平苔癣 中医传承辅助平台 数据挖掘 用药经验分析

2024年首都卫生发展科研专项项目首都医学科技创新成果转化优促计划项目全国中医临床优秀人才研修项目北京市医院管理中心"登峰"人才培养计划

2024-2-2237YC202301JS0053国中医药人教函[2022]1号DFL20220801

2024

世界中西医结合杂志
中华中医药学会

世界中西医结合杂志

CSTPCD
影响因子:1.053
ISSN:1673-6613
年,卷(期):2024.19(9)
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