Jiedu Zhuyu Mieban Decoction Treats Keloids after Acne via MAPK Signaling Pathway
Objective To investigate the effect of Jiedu Zhuyu Mieban Decoction on the mitogen-activated pro-tein kinase(MAPK)signaling pathway in treating keloids after acne.Methods A total of 86 patients with keloids after ac-ne diagnosed and treated in Hengshui Hospital of Traditional Chinese Medicine from January 2020 to January 2023 were selected and assigned into study and control groups(n=43)by the simple random number table method.The control group was treated with recombinant bovine basic fibroblast growth factor gel,and the study group was treated with Jiedu Zhuyu Mieban Decoction.Both groups were treated for 3 months,and the efficacy,adverse reactions,and recurrence rate were compared between the two groups.The traditional Chinese medicine(TCM)symptom scores,scar severity score,and levels of proteins in the MAPK signaling pathway were determined before and after treatment.Results The total response rate in the study group was 97.67%(42/43),which was higher than that(83.72%,36/43)in the control group(P<0.05).After treatment,the scores of skin lesions,redness and swelling,burning pain,pustules,nodules or cysts,insomnia and dreami-ness,vexation,bitter mouth,dry mouth,and body heat declined(P<0.05),and the scores in the study group were lower than those in the control group(P<0.05).After treatment,the score of scar severity(including thickness,softness,blood vessel distribution,and color)declined in the two groups(P<0.05)and it was lower in the study group than in the control group(P<0.05).The treatment in both groups down-regulated the levels of P38 and c-Jun N-terminal kinase(JNK)and up-regulated the level of extracellular signal-regulated kinase(ERK)(P<0.05),and the study group had lower levels of P38 and JNK and higher level of ERK than the control group after treatment(P<0.05).The incidence of adverse reactions and the reoccurrence rate showed no significant difference between the two groups(P>0.05).Conclusion Jiedu Zhuyu Mieban Decoction can treat keloids after acne by regulating the MAPK/ERK signaling pathway.
Jiedu Zhuyu Mieban DecoctionKeloid after AcneTraditional Chinese Medicine(TCM)Symptom ScoreScar SeverityMitogen-Activated Protein Kinase(MAPK)Signaling Pathway