首页|解毒逐瘀灭瘢汤治疗痤疮后瘢痕疙瘩患者的临床疗效及对其MAPK信号通路的影响

解毒逐瘀灭瘢汤治疗痤疮后瘢痕疙瘩患者的临床疗效及对其MAPK信号通路的影响

扫码查看
目的 探讨解毒逐瘀灭瘢汤治疗痤疮后瘢痕疙瘩患者的临床疗效及对其MAPK信号通路的影响.方法 选取2020年1月—2023年1月期间于衡水市中医医院诊治的86例痤疮后瘢痕疙瘩患者,采用简单随机数字表法分为研究组和对照组,每组各46例.对照组给予重组牛碱性成纤维细胞生长因子凝胶治疗,研究组给予解毒逐瘀灭瘢汤治疗,连续治疗3个月.观察比较两组患者临床疗效、不良反应及复发率,治疗前后中医证候积分、瘢痕严重程度评分、MAPK信号通路.结果 治疗后研究组总有效率97.67%(42/43)明显高于对照组83.72%(36/43),差异有统计学意义(P<0.05).治疗后两组患者中医证候积分皮损红肿、灼热疼痛、伴脓疱、结节或囊肿、失眠多梦、心烦、口苦、口干、身热评分均低于治疗前,差异有统计学意义(P<0.05);且研究组中医证候积分皮损红肿、灼热疼痛、伴脓疱、结节或囊肿、失眠多梦、心烦、口苦、口干、身热评分均明显低于对照组,差异有统计学意义(P<0.05).治疗后两组患者瘢痕严重程度(厚度、瘢痕柔软度、血管分布、色泽评分)均低于治疗前,差异有统计学意义(P<0.05);且研究组瘢痕严重程度(厚度、瘢痕柔软度、血管分布、色泽评分)均明显低于对照组,差异有统计学意义(P<0.05).治疗后两组患者P38、JNK均低于治疗前,ERK高于治疗前,差异有统计学意义(P<0.05);且研究组P38、JNK均明显低于对照组,ERK明显高于对照组,差异有统计学意义(P<0.05).治疗期间,两组患者不良反应及复发率比较,差异无统计学意义(P>0.05).结论 解毒逐瘀灭瘢汤能够通过调节MAPK/ERK信号通路有效治疗痤疮后瘢痕疙瘩.
Jiedu Zhuyu Mieban Decoction Treats Keloids after Acne via MAPK Signaling Pathway
Objective To investigate the effect of Jiedu Zhuyu Mieban Decoction on the mitogen-activated pro-tein kinase(MAPK)signaling pathway in treating keloids after acne.Methods A total of 86 patients with keloids after ac-ne diagnosed and treated in Hengshui Hospital of Traditional Chinese Medicine from January 2020 to January 2023 were selected and assigned into study and control groups(n=43)by the simple random number table method.The control group was treated with recombinant bovine basic fibroblast growth factor gel,and the study group was treated with Jiedu Zhuyu Mieban Decoction.Both groups were treated for 3 months,and the efficacy,adverse reactions,and recurrence rate were compared between the two groups.The traditional Chinese medicine(TCM)symptom scores,scar severity score,and levels of proteins in the MAPK signaling pathway were determined before and after treatment.Results The total response rate in the study group was 97.67%(42/43),which was higher than that(83.72%,36/43)in the control group(P<0.05).After treatment,the scores of skin lesions,redness and swelling,burning pain,pustules,nodules or cysts,insomnia and dreami-ness,vexation,bitter mouth,dry mouth,and body heat declined(P<0.05),and the scores in the study group were lower than those in the control group(P<0.05).After treatment,the score of scar severity(including thickness,softness,blood vessel distribution,and color)declined in the two groups(P<0.05)and it was lower in the study group than in the control group(P<0.05).The treatment in both groups down-regulated the levels of P38 and c-Jun N-terminal kinase(JNK)and up-regulated the level of extracellular signal-regulated kinase(ERK)(P<0.05),and the study group had lower levels of P38 and JNK and higher level of ERK than the control group after treatment(P<0.05).The incidence of adverse reactions and the reoccurrence rate showed no significant difference between the two groups(P>0.05).Conclusion Jiedu Zhuyu Mieban Decoction can treat keloids after acne by regulating the MAPK/ERK signaling pathway.

Jiedu Zhuyu Mieban DecoctionKeloid after AcneTraditional Chinese Medicine(TCM)Symptom ScoreScar SeverityMitogen-Activated Protein Kinase(MAPK)Signaling Pathway

鲍希静、李向阳、李彩玲、段倩宏、刘屹

展开 >

衡水市中医医院皮肤科,河北衡水 053000

武邑县中医医院内科,河北衡水 053000

衡水市 中医医院针灸科,河北衡水 053000

衡水市中医医院医务科,河北衡水 053000

衡水市中医医院药剂科,河北衡水 053000

展开 >

解毒逐瘀灭瘢汤 痤疮后瘢痕疙瘩 中医证候积分 瘢痕严重程度 MAPK信号通路

河北省中医药管理局科研计划项目

2022618

2024

世界中西医结合杂志
中华中医药学会

世界中西医结合杂志

CSTPCD
影响因子:1.053
ISSN:1673-6613
年,卷(期):2024.19(9)
  • 23