Clinical Efficacy of Modified Zhiwei Decoction Combined with Quadruple Therapy in Treatment of Chronic Atrophic Gastritis and Its Influence on TCM Syndrome Score,Pepsinogen,and Inflammatory Factors
Objective To observe the clinical efficacy of modified Zhiwei Decoction combined with the quadruple therapy in treating patients with chronic atrophic gastritis(CAG)and its effect on traditional Chinese medicine(TCM)syn-drome scores,serum pepsinogen levels,and inflammatory factors.Methods A total of 100 CAG patients admitted to the Gastroenterology Department of Guangyuan Traditional Chinese Medicine Hospital from April 2021 to April 2022 were en-rolled and randomly divided into a control group and a treatment group according to a random number table,with 50 cases in each group.The control group received quadruple therapy,while the treatment group was additionally treated with the modified Zhiwei Decoction based on the treatment of the control group.After six treatment cycles,the clinical efficacy,ad-verse reactions,TCM syndrome scores,and serum inflammatory factors[interleukin 4(IL-4),interleukin 10(IL-10),tumor necrosis factor-alpha(TNF-α)],as well as serum levels of pepsinogen Ⅰ(PG Ⅰ),pepsinogen Ⅱ(PG Ⅱ),gastrin(GAS),epidermal growth factor(EGF),and vascular cell adhesion molecule-1(VC AM-1)before and after treatment were compared between the two groups.Results After treatment,the total effective rate in the treatment group was 92.00％(46/50),significantly higher than 76.00％(38/50)in the control group(P＜0.05).Both groups showed a signif-icant decrease in IL-4,IL-10,and TNF-α levels after treatment compared with those before treatment(P＜0.05),with the treatment group exhibiting significantly lower levels of IL-4,IL-10,and TNF-α than the control group(P＜0.05).The primary symptom scores,secondary symptom scores,and total scores in both groups were lower after treatment than those before treatment(P＜0.05).The primary symptom score,secondary symptom score,and total score in the treatment group were significantly lower than those of the control group(P＜0.05).In both groups,serum PG Ⅰ and GAS levels de-creased after treatment,while PG Ⅱ levels increased(P＜0.05).The PG Ⅰ and GAS levels of the treatment group were sig-nificantly lower than those of the control group,while PG Ⅱ levels were significantly higher(P＜0.05).The treatment group showed increased serum EGF levels and decreased VCAM-1 levels after treatment(P＜0.05).Serum EGF levels in the treatment group were significantly higher and VC AM-1 levels were significantly lower than those in the control group(P＜0.05).No adverse reactions occurred in either group during the treatment period.Conclusion Modified Zhi-wei Decoction combined with quadruple therapy significantly improves clinical symptoms in CAG patients and effectively regulates serum inflammatory factors,PG Ⅰ,PG Ⅱ,EGF,and VC AM-1 levels.
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