Clinical Efficacy of Modified Shechuangzi Powder by Professor Cheng Ling in Treat-ment of Vulvar Lichen Sclerosus in Young Girls
Objective To evaluate the clinical efficacy of Professor Cheng Ling's modified Shechuangzi Powder in the treatment of vulvar lichen sclerosus(VLS)in young girls.Methods A total of 68 pediatric patients diagnosed with VLS who visited the pediatric gynecology clinic at the Maternal and Child Health Hospital in Shunyi District,Beijing,be-tween December 2019 and December 2022 were enrolled and randomly divided into a control group and a treatment group using a random number table,with 34 cases in each group.The control group was treated with hydrocortisone butyrate cream,while the treatment group received Professor Cheng Ling's modified Shechuangzi Powder combined with hydrocorti-sone butyrate cream.After 12 weeks of treatment,the clinical efficacy,recurrence rate,and adverse reactions were com-pared between the two groups.Additionally,clinical symptom scores,physical sign scores,the Xie-Kawashima itch severi-ty scores,and skin scores were assessed before and after treatment.Results After one month of treatment,the skin color and Xie-Kawashima(daytime and nighttime)scores in both groups significantly improved compared to baseline(P＜0.05),with no significant difference in skin elasticity scores compared to baseline(P＞0.05).There were no significant differences between the two groups in skin color,skin elasticity,or Xie-Kawashima(daytime and nighttime)scores after one month of treatment(P＞0.05).After three months of treatment,both groups showed significant improvements in skin color,skin elasticity,and Xie-Kawashima(daytime and nighttime)scores compared to baseline(P＜0.05).Furthermore,the treatment group exhibited significantly greater reductions in skin color and Xie-Kawashima(daytime and nighttime)scores than the control group(P＜0.05).The total effective rate in the treatment group was 94.12％(32/34),significantly higher than the 85.29％(29/34)in the control group(P＜0.05).During the follow-up period,the recurrence rate in the treatment group was 5.88％(2/34),which was significantly lower than 17.65％(6/34)in the control group(P＜0.05).No abnormal adverse reactions,such as changes in blood tests,liver and kidney function,or electrocardiograms,were ob-served in either group during the treatment.Conclusion Professor Cheng Ling's modified Shechuangzi Powder demon-strates good clinical efficacy in treating VLS in young girls,which can effectively alleviate itching and improve skin color in a relatively short period,with a lower recurrence rate.
万方数据
维普
