Clinical Effect of Self-designed Shenqi Dihuang Decoction on Refractory Intradia-lytic Hypotension in Patients Undergoing Maintenance Hemodialysis for End-Stage Renal Disease
Objective To observe the clinical efficacy of Shenqi Dihuang Decoction in the treatment of refractory intradialytic hypotension(IDH)in the patients undergoing maintenance hemodialysis for end-stage renal disease.Methods A total of 81 patients with end-stage renal disease who were prone to refractory IDH during maintenance hemodialysis in Baoji Hospital of Traditional Chinese Medicine from January 2022 to October 2023 were assigned with the random number table method into a control group(n=41)and an observation group(n=40).The control group received conventional Western medicine intervention,and the observation group was treatment with self-designed Shenqi Dihuang Decoction on the basis of the therapy in the control group.After 8 weeks of treatment,the clinical efficacy was compared between the two groups.The TCM symptom score and blood pressure indicators[systolic blood pressure(SBP),diastolic blood pressure(DBP),and mean arterial pressure(MAP)]were determined before and after treatment.The proportions of IDH,muscle cramps,early termination of dialysis,and getting up directly after dialysis in the two groups were statistically analyzed.The adequacy of dialysis in both groups was assessed.Results The total response rate in the observation group was 90.00％(36/40),which was higher than that(68.29％,29/41)in the control group(P＜0.05).After treatment,the TCM symp-tom score declined in both groups(P＜0.05),and the score in the observation group was lower than that in the control group(P＜0.05).There was no statistically significant difference(P＞0.05)in the SBP,DBP,and MAP between the two groups before and during dialysis.Before treatment,the SBP,DBP,and MAP during dialysis in both groups were lower than those before dialysis(P＜0.05).After treatment,the SBP,DBP,and MAP during dialysis in the observation group were higher than those in the same period before treatment and also higher than those in the control group(P＜0.05).The ob-servation group had lower proportions of IDH,muscle cramps,and early termination of dialysis and higher proportion of get-ting up directly after dialysis than the control group(P＜0.05).After treatment,the Kt/V value,urea reduction ratio(URR),and ultrafiltration indicators increased in the two groups(P＜0.05),and they were higher in the observation group than in the control group(P＜0.05).Conclusion Self-designed Shenqi Dihuang Decoction can significantly re-duce the incidence of refractory IDH in the patients undergoing maintenance hemodialysis for end-stage renal disease.It not only alleviates symptoms but also maintains stable blood pressure during dialysis,being conducive to improving dialysis adequacy and effect and worthy of promotion in clinical practice.
Shenqi Dihuang DecoctionEnd-Stage Renal DiseaseMaintenance HemodialysisIntradialytic Hy-potensionSyndrome of Q-Yin DeficiencyL-Carnitine
万方数据
维普
