Clinical Efficacy of Shenling Baizhu Powder Combined with Acupuncture and Moxi-bustion on Allergic Rhinitis with Qi Deficiency in Lungs and Spleen Syndrome and Effect on Serum IFN-γ and IL-17 Levels
Objective To observe the efficacy of Shenling Baizhu Powder combined with acupuncture and moxi-bustion in allergic rhinitis patients with lung-spleen qi deficiency syndrome and its effect on serum levels of interferon-γ(IFN-γ)and interleukin-17(IL-17).Methods A total of 100 allergic rhinitis patients admitted to Qinhuangdao Maternal and Child Health Hospital from January 2020 to January 2023 were enrolled and randomly divided into a control group and an observation group according to a random number table,with 50 patients in each group.The control group re-ceived oral Shenling Baizhu Powder,while the observation group received acupuncture and moxibustion in addition to the control treatment.Both groups underwent treatment for 30 days.Clinical efficacy,adverse reactions,traditional Chinese medicine(TCM)syndrome scores,serum IFN-γ and IL-17 levels,and immune function levels[CD3+,CD4+,CD8+,CD4+/CD8+]before and after treatment were compared.Results The clinical total effective rate in the observation group was 96.00％(48/50),significantly higher than 74.00％(37/50)in the control group(P＜0.05).After treatment,scores for nasal itching,nasal congestion,shortness of breath,runny nose,and sneezing significantly decreased in both groups com-pared to those before treatment(P＜0.05),with the observation group scoring lower than the control group(P＜0.05).Se-rum IFN-γ levels increased and IL-17 levels decreased in both groups after treatment(P＜0.05),and the observation group had significantly higher IFN-γ levels and lower IL-17 levels than the control group(P＜0.05).Immune function levels(CD3+,CD4+,CD4+/CD8+)increased,while CD8+levels decreased in both groups after treatment(P＜0.05),and the observation group had significantly higher CD3+,CD4+,and CD4+/CD8+levels and lower CD8+levels than the control group(P＜0.05).There were no significant differences in adverse reaction rates between the two groups during treatment(P＞0.05).Conclusion Shenling Baizhu Powder combined with acupuncture and moxibustion demonstrates significant efficacy in treating lung-spleen qi deficiency type allergic rhinitis,effectively improving clinical symptoms,in-creasing serum IFN-γ levels,and decreasing IL-17 levels,thus playing a role in immune regulation.This treatment is worthy of clinical promotion and application.
Shenling Baizhu PowderAcupuncture and MoxibustionAllergic RhinitisInterferon-γInterleukin-17
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