Clinical Curative Effect of Bushen Juanbi Decoction Combined with Acupuncture and Its Influences on Serum Transforming Growth Factor-β1 and Prostaglandin E2 in Patients with Frozen Shoulder
Objective To explore the clinical curative effect of Bushen Juanbi Decoction combined with acupunc-ture and its influences on serum transforming growth factor-β1(TGF-β1)and prostaglandin E2(PGE2)in patients with frozen shoulder(FS).Methods According to the random number table method,120 patients with FS(cold-dampness obstruction syndrome)admitted to Shijiazhuang People's Hospital between October 2021 and October 2023 were divided in-to a control group(60 cases)and an experimental group(60 cases).The control group was treated with oral diclofenac sodi-um,while the experimental group was treated with Bushen Juanbi Decoction and acupuncture.The two groups were both treated for 4 weeks.The clinical curative effect was compared between the two groups.In addition,comparison was also per-formed on the traditional Chinese medicine(TCM)syndrome scores,serum inflammatory indexes[TGF-β1,PGE2,C-re-active protein(CRP),and tumor necrosis factor-α(TNF-α)],shoulder joint recovery[visual analog scale(VAS)and Constant-Murley scale(CMS)],incidence of adverse reactions,and recurrence rate.Results After treatment,the total clinical effective rate of the experimental group was higher than that of the control group[95.00%(57/60)vs 80.00%(48/60),P<0.05].After treatment,TCM syndrome scores were decreased in both groups(P<0.05),which were lower in the experimental group than in the control group(P<0.05).After treatment,the levels of TGF-β1,PGE2,CRP,and TNF-α were decreased in both groups(P<0.05),which were lower in the experimental group than in the control group(P<0.05).After treatment,the VAS scores were decreased in both groups(P<0.05),which were lower in the experi-mental group than in the control group(P<0.05).Additionally,the CMS scores were increased after treatment(P<0.05),which were higher in the experimental group than in the control group(P<0.05).There were significant differ-ences in the incidence of adverse reactions and the recurrence rate between the two groups(P<0.05).Conclusion The curative effect of Bushen Juanbi Decoction combined with acupuncture is significant on patients with FS(cold-dampness obstruction syndrome),which can effectively improve TCM syndromes,reduce levels of serum inflammatory factors,promote the recovery of shoulder joint function,and strengthen self-care ability with high safety and a low recurrence rate.
Frozen ShoulderBushen Juanbi DecoctionAcupunctureDiclofenac SodiumSerum Index