目的 探讨葛根芩连汤加减治疗胃肠湿热型2型糖尿病糖脂代谢紊乱患者的临床疗效.方法 选取2022年8月-2023年8月期间在保定市中医院就诊的120例糖脂代谢紊乱患者,按随机数字表法分为对照组和观察组,每组各60例.对照组常规采取饮食控制、运动疗法、常规降糖降脂药物治疗,观察组在对照组基础上采用葛根芩连汤加减治疗,8周为1个疗程,共治疗2个疗程.观察比较两组患者临床疗效、不良反应发生情况,治疗前后血糖[空腹血糖(Fasting blood glucose,FBG)、2 h 血糖(2 hour postprandial blood glucose,2 h PG)、糖化血红蛋白(Glycosylated hemoglobin,HbA1c)]、血脂[总胆固醇(Total cholestero,TC)、甘油三酯(Triglyceride,TG)、低密度脂蛋白胆固醇(Low density lipoprotein cholesterol,LDL-C)、高密度脂蛋白胆固醇(High density lipoprotein cholesterol,HDL-C)]、体质量指数(Body mass index,BMI)水平、中医证候积分.结果 治疗后两组患者HbA1c、FBG、2 h PG水平均较治疗前降低,差异有统计学意义(P＜0.05);且观察组血糖指标明显低于对照组,差异有统计学意义(P＜0.05).治疗后两组患者TC、TG、LDL-C水平均较治疗前降低,HDL-C水平较治疗前升高,差异有统计学意义(P＜0.05);且观察组TC、TG、LDL-C水平明显低于对照组,HDL-C水平明显高于对照组,差异有统计学意义(P＜0.05);而两组患者BMI水平均出现轻微变化,但组间比较,差异无统计学意义(P＞0.05).治疗后两组患者中医证候积分均较治疗前降低,差异有统计学意义(P＜0.05);且观察组中医证候积分明显低于对照组,差异有统计学意义(P＜0.05).治疗后观察组临床总有效率88.33％(53/60)明显高于对照组73.33％(44/60),差异有统计学意义(P＜0.05).治疗期间,观察组不良反应总发生率8.33％(5/60)与对照组11.67％(7/60)比较,差异无统计学意义(P＞0.05).结论 葛根芩连汤加减可有效降低胃肠湿热型2型糖尿病糖脂代谢紊乱患者的血糖、血脂水平,并明显改善症状,且安全性较高,具有良好的临床疗效及应用价值.
Efficacy of Modified Gegen Qinlian Decoction in Treating Patients with Gastrointes-tinal Damp-Heat Type 2 Diabetes and Glycolipid and Metabolism Disorders
Objective To explore the clinical efficacy of modified Gegen Qinlian decoction in treating patients with gastrointestinal damp-heat type 2 diabetes and glycolipid metabolism disorders.Methods A total of 120 patients with glycolipid metabolism disorders who visited Baoding Hospital of Traditional Chinese Medicine between August 2022 and August 2023 were selected.The patients were randomly divided into a control group and an observation group,with 60 patients in each group.The control group received conventional treatment,including dietary control,exercise therapy,and standard glucose-and lipid-lowering medications.The observation group received modified Gegen Qinlian decoction in addition to the treatments given to the control group.Each course lasted for 8 weeks,and two courses of treatment were ad-ministered.Clinical efficacy,adverse reactions,and pre-and post-treatment levels of blood glucose[fasting blood glucose(FBG),2-hour postprandial blood glucose(2 h PG),glycosylated hemoglobin(HbA1c)],blood lipids[total cholesterol(TC),triglycerides(TG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C)],body mass index(BMI),and traditional Chinese medicine(TCM)syndrome scores compared between the two groups.Results After treatment,both groups showed significant reductions in HbA1c,FBG,and 2h PG levels compared to before treatment,with statistically significant differences(P＜0.05);the observation group showed significantly lower blood glucose levels than the control group,with statistically significant differences(P＜0.05).Both groups also showed significant re-ductions in TC,TG,and LDL-C levels and increased HDL-C levels after treatment,with statistically significant differ-ences(P＜0.05);the observation group showed more pronounced improvements in lipid profiles than the control group,with statistically significant differences(P＜0.05).There was a slight change in BMI levels in both groups,but the differ-ence between the two groups was not statistically significant(P＞0.05).TCM syndrome scores were significantly reduced in both groups after treatment,with a statistically significant difference(P＜0.05);the observation group showed signifi-cantly lower scores than the control group,with a statistically significant difference(P＜0.05).The total clinical efficacy rate in the observation group was 88.33％(53/60),significantly higher than 73.33％(44/60)in the control group,with a statistically significant difference(P＜0.05).The incidence of adverse reactions was 8.33％(5/60)in the observation group compared to 11.67％(7/60)in the control group,with no statistically significant difference(P＞0.05).Conclusion Modified Gegen Qinlian decoction effectively reduces blood glucose and lipid levels in patients with gastrointestinal damp-heat of type 2 diabetes and glycolipid metabolism disorders.It significantly improves symptoms and has a high safety pro-file,making it a valuable treatment with good clinical efficacy.
Type 2 DiabetesHyperlipidemiaGlycosylated HemoglobinGegen Qinlian Decoction
万方数据
维普
