Clinical Efficacy and Safety of the Qingre Lishi Zhushui Modified Formula in Trea-ting Patients with Dampness-Heat Accumulated Liver Cirrhosis Ascites
Objective To explore the clinical effect and safety of Qingre Lishi Zhushui modified formula in trea-ting patients with dampness-heat accumulated liver cirrhosis ascites.Methods From January 2020 to May 2023,86 pa-tients with liver cirrhosis ascites treated at Shijiazhuang Hospital of Traditional Chinese Medicine were selected and divided into a control group and a study group according to a simple random number table method,with 43 cases in each group.The control group received conventional treatment,while the study group received the Qingre Lishi Zhushui modified formula in addition to the conventional treatment.Both groups were treated for 4 weeks.The study assessed traditional Chinese medi-cine(TCM)syndrome scores,physical condition(ascites depth,24-hour average urine output,abdominal circumference,and fasting body weight),liver function indicators[total bilirubin(TBil),glutamyltranspeptidase(GGT),aspartate amin-otransferase(AST),alanine aminotransferase(ALT)],clinical efficacy,and incidence of adverse reactions before and after treatment.Results After treatment,the overall clinical efficacy in the study group was 93.02%(40/43),significantly higher than 76.74%(33/43)in the control group,with a statistically significant difference(P<0.05).After treatment,the TCM syndrome scores,including symptoms such as epigastric and abdominal distension,hardened and full abdomen,consti-pation,reddish and scanty urine,lack of thirst,fever with bitter mouth,and yellowish complexion,were significantly reduced in both groups compared to pre-treatment levels,with statistically significant differences(P<0.05).The TCM syndrome scores in the study group were significantly lower than those in the control group,with statistically significant differences(P<0.05).After treatment,both groups showed significant reductions in ascites depth,abdominal circumference,and fast-ing body weight,and an increase in 24-hour urine output,with statistically significant differences(P<0.05).The ascites depth,abdominal circumference,and fasting body weight in the study group were lower than those in the control group,while the 24-hour urine output was higher than that in the control group,with statistically significant differences(P<0.05).After treatment,TBil,GGT,AST,and ALT levels were significantly reduced in both groups compared to before treat-ment,with statistically significant differences(P<0.05);the liver function of the study group was significantly lower than that of the control group,with statistically significant differences(P<0.05).The incidence of adverse reactions in the study group was 11.63%(5/43),compared to 6.98%(3/43)in the control group,with no statistically significant difference(P>0.05).Conclusion The Qingre Lishi Zhushui modified formula is effective in relieving clinical symptoms,reducing ascites,improving physical condition and liver function,and enhancing the overall treatment efficacy in damp-heat accu-mulated liver cirrhosis ascites.The treatment is also considered safe.
Qingre Lishi Zhushui Modified FormulaLiver Cirrhosis ascitesDamp-Heat AccumulationLiver function