首页|阳和汤联合曲安奈德注射治疗肉芽肿性小叶性乳腺炎患者的疗效观察

阳和汤联合曲安奈德注射治疗肉芽肿性小叶性乳腺炎患者的疗效观察

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目的 探讨阳和汤联合曲安奈德注射治疗阳虚痰凝证肿块型肉芽肿性小叶性乳腺炎(Granulomatous lobular mastitis,GLM)的临床疗效.方法 选取2022年12月—2023年10月期间潍坊市中医院收治的60例阳虚痰凝证肿块型GLM患者,按随机数字表法分为对照组和治疗组,每组各30例.对照组采用肿块内曲安奈德注射治疗,治疗组在对照组的基础上予以阳和汤治疗.两组患者治疗周期均为8周.观察比较两组患者治疗前后中医证候积分、炎症指标[降钙素原(Procalcitonin,PCT)、白细胞介素-6(Interleukin-6,IL-6)和C反应蛋白(C-reacyive protein,CRP)]水平及临床疗效.结果 治疗后治疗组临床总有效率96.67%(29/30)明显高于对照组83.33%(25/30),差异有统计学意义(P<0.05).治疗后两组患者中医证候积分均较治疗前降低,差异有统计学意义(P<0.01);且治疗组中医证候积分明显低于对照组,差异有统计学意义(P<0.05).治疗后两组患者PCT、CRP和IL-6水平均较治疗前降低,差异有统计学意义(P<0.05);且治疗组PCT、CRP和IL-6水平均明显低于对照组,差异有统计学意义(P<0.05).结论 阳和汤内服联合使用曲安奈德治疗GLM的临床效果显著,可以改善中医证候,提高整体治疗效果.
Efficacy of Yanghe Decoction Combined with Triamcinolone Acetonide Injection in the Intervention of Granulomatous Lobular Mastitis
Objective To investigate the clinical efficacy of Yanghe Decoction combined with triamcinolone ace-tonide injection in the treatment of mass-type granulomatous lobular mastitis(GLM)with the syndrome of yang deficiency and phlegm coagulation.Methods Sixty patients of mass-type GLM with the syndrome of yang deficiency and phlegm coagulation who were treated in Weifang Hospital of Traditional Chinese Medicine between December 2022 and October 2023 were chosen and divided into a treatment group and a control group with the random number table method.The con-trol group was treated with triamcinolone acetonide injection in the mass,while the treatment group received Yanghe Decoc-tion in addition to the drug used by the control group.Both groups were treated for 8 weeks.The efficacy was evaluated by comparing the changes of traditional Chinese medicine(TCM)syndrome scores and inflammatory markers[procalcitonin(PCT),interleukin-6(IL-6),and C-reactive protein(CRP)]between the two groups before and after treatment.Re-sults After treatment,the total clinical effective rate of 96.67%(29/30)in the treatment group was significantly higher than that of 83.33%(25/30)in the control group(P<0.05).The TCM syndrome scores of the two groups after treatment were lower than those before treatment(P<0.01),and the TCM syndrome scores were lower in the treatment group than in the control group(P<0.05).Treatment reduced PCT,CRP,and IL-6 levels in the two groups(P<0.05),and their lev-els were significantly lower in the treatment group than in the control group(P<0.05).Conclusion The clinical efficacy of Yanghe Decoction combined with triamcinolone acetonide injection is significant in the treatment of GLM,which can im-prove TCM syndromes and enhance the treatment effect.

Yanghe DecoctionMass-type Granulomatous MastitisYang Deficiency and Phlegm CoagulationTriamcinolone Acetonide

郝晓亮、张艳辉、李艳敏、王飞、李高峰、马晓东、闫文文

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潍坊市中医院乳腺甲状腺外科,山东潍坊 261041

潍坊市人民医院创伤骨科,山东潍坊 261041

阳和汤 肿块型肉芽肿性乳腺炎 阳虚痰凝 曲安奈德

2024

世界中西医结合杂志
中华中医药学会

世界中西医结合杂志

CSTPCD
影响因子:1.053
ISSN:1673-6613
年,卷(期):2024.19(11)