Curative Effect of Qiangjin Jiangu Prescription Combined with Alendronate Sodium in the Treatment of Osteoporosis of Liver and Kidney Deficiency Type from Multi-dimensional Perspective
Curative Effect of Qiangjin Jiangu Prescription Combined with Alendronate Sodium in the Treatment of Osteoporosis of Liver and Kidney Deficiency Type from Multi-dimensional Perspective
Objective To analyze the curative effect of Qiangjin Jiangu prescription combined with alendronate sodium in the treatment of osteoporosis of the liver and kidney deficiency type from a multi-dimensional perspective.Methods 120 patients with osteoporosis of the liver and kidney deficiency type who were treated in the Department of Rheumatology,Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine from June 2023 to June 2024 were selected as the study subjects.They were divided into an observation group and a control group according to the ran-dom number table method,with 60 cases in each group.The control group was treated with calcium carbonate chewable tab-lets+alfacalcidol soft capsules+alendronate sodium enteric-coated tablets,while the observation group was treated with Qiangjin Jiangu prescription in addition to the therapeutic method adopted by the control group.The treatment lasted for six consecutive months.The clinical efficacy of the two groups of patients was observed and compared.Evaluation was made on the levels of erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),blood calcium,parathyroid hormone(PTH),bone metabolism indicators[procollagen Ⅰ C-terminal propeptide(PⅠ CP),bone alkaline phosphatase(BALP),cross-linked C-telopeptide of type Ⅰ collagen(ⅠCTP),and bone γ-carboxyglutamic acid(BGP)],bone mineral densi-ty(lumbar vertebrae and femoral neck)before and after treatment to assess the degree of pain in patients[visual analogue scale(VAS)].Results The total effective rate of the observation group(90.00％,54/60)was higher than that of the con-trol group(70.00％,42/60)after treatment(P＜0.05).In both groups,the ESR,CRP,and PTH levels were decreased,and the blood calcium level was increased after treatment(P＜0.05).In addition,the ESR,CRP,and PTH levels were low-er,and the blood calcium level was higher in the observation group compared with the control group(P＜0.05).The levels of P ⅠCP,BALP,and BGP were elevated,while the Ⅰ CTP level declined after treatment in both groups(P＜0.05),with the observation group showing higher P Ⅰ CP,BALP,and BGP levels and a lower Ⅰ CTP level(P＜0.05).The bone mineral densities of lumbar vertebrae and right femoral neck did not exhibit significant differences before and after treatment in the control group(P＞0.05),while those in the observation group were enhanced after treatment compared with before treat-ment(P＜0.05).Additionally,the bone mineral densities of lumbar vertebrae and right femoral neck were higher in the observation group than in the control group(P＜0.05).Compared with those before treatment,VAS scores in both groups were decreased after treatment(P＜0.05),with the observation group exhibiting lower VAS scores than the control group(P＜0.05).Conclusion The combination of Qiangjin Jiangu prescription with alendronate sodium can effectively im-prove the clinical efficacy of patients with osteoporosis of the liver and kidney deficiency type and reduce the degree of pain,whose mechanism of action may be related to that the treatment plan is more beneficial to improvement of body in-flammatory response,regulation of bone metabolism,and enhancement of bone strength.
关键词
骨质疏松症/肝肾亏虚型/强筋健骨方/阿仑膦酸钠
Key words
Osteoporosis/Liver and Kidney Deficiency Type/Qiangjin Jiangu Prescription/Alendronate Sodium
维普
万方数据