摘要
目的：探析肺腺癌 EGFR 突变的肿瘤标志物、影像学特点及临床特征。方法选取我院经手术确诊的115例肺腺癌患者为研究资料，均采用焦磷酸测序法进行检测，对肺腺癌 EGFR 突变的肿瘤标志物、影像学特点及临床特征进行回顾性评价。结果肺腺癌 EGFR 总体突变率为65.22%，男性与女性间、吸烟者与非吸烟者间、高中低分化间的基因突变率有显著差异（P<0.05）；伴有空泡或空洞性病变的突变率相对较高；肿瘤突变率与肺腺癌病灶直径、血管集束征等临床特征无明显相关性。结论肺腺癌 EGFR 突变与患者的性别、吸烟指数、基因突变程度等均有密切联系，且经影像学检查，病灶伴有空泡或空洞性病变的突变率较高，为临床诊断和治疗提供依据。
Abstract
Objective To study tumor markers, imaging features and clinical features of EGFR mutation in lung adenocarcinoma. Methods select 115 cases lung adenocarcinoma diagnosed by operation in our hospital as research data. All patients were tested by pyrosequencing, and review and evaluate tumor markers, imaging features and clinical features of EGFR mutation in lung adenocarcinoma. Results overall rate of EGFR mutation in lung adenocarcinoma was 65.22%, and gene mutation rate of male and female, smokers and non-smokers, high, middle and low differentiation has significant difference (P < 0.05); mutation rate with bubble or cavity lesions is relatively high; mutation rate of tumour has no significant correlation with clinical characteristics of diameter of lung adenocarcinoma tumor lesions and vascular convergence signs. Conclusion EGFR mutation in lung adenocarcinoma is closely related with gender, smoking index and gene mutation degree of patients, and after imaging examination, mutation rate is high with bubble or cavity lesions, which provides basis for clinical diagnosis and treatment.
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