首页|消脂清肝方辨证加减治疗代谢相关脂肪性肝病的临床观察

消脂清肝方辨证加减治疗代谢相关脂肪性肝病的临床观察

Clinical Observation on the Treatment of Metabolic-associated Fatty Liver Disease with Modified Xiaozhi Qinggan Formula Based on Syndrome Differentiation

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目的:探究消脂清肝方辨证加减对代谢相关脂肪性肝病(MAFLD)患者脂代谢、抗氧化能力及肝纤维化的影响.方法:选取2020年6月至2023年2月辽宁中医药大学附属医院收治的MAFLD患者85例作为研究对象,按照随机数字表法随机为对照组(n=42)和观察组(n=43).对照组饮食控制和运动指导治疗,观察组在对照组基础给予消脂清肝方辨证加减治疗,2组均连续治疗1个月.比较2组患者临床疗效、中医证候积分、脂代谢、抗氧化能力和肝纤维化指标.结果:观察组临床总有效率为90.70%,较对照组的71.43%显著提高(P>0.05);与治疗前比较,2组患者治疗后各项中医证候积分均显著下降,观察组较对照组更明显(P<0.05);三酰甘油(TG)、胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、肝脏硬度值和脂肪衰减值均下降,高密度脂蛋白胆固醇(HDL-C)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)水平均明显升高,且观察组优于对照组(P<0.05).结论:MAFLD患者应用消脂清肝方辨证加减治疗,疗效显著,可有效改善脂代谢指标,提高抗氧化能力,减轻肝纤维化程度.
Objective:To investigate the effect of modified Xiaozhi Qinggan Formula based on syndrome differentiation on lipid me-tabolism,antioxidant capacity and hepatic fibrosis in patients with metabolic-associated fatty liver disease(MAFLD).Methods:A total of 85 patients with MAFLD admitted to the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine from June 2020 to February 2023 were assigned to the control group(n=42)and the observation group(n=43)by random number ta-ble method.The control group was given dietary control and exercise guidance,while the observation group was treated with modi-fied Xiaozhi Qinggan Formula based on syndrome differentiation in addition to the basic treatment of the control group.Both groups underwent continuous treatment for one month.Clinical efficacy,traditional Chinese medicine(TCM)syndrome scores,lipid metab-olism,antioxidant capacity and hepatic fibrosis indicators were compared between the two groups.Results:The total clinical effec-tive rate in the observation group(90.70%)was significantly higher than that in the control group(71.43%)(P<0.05).Com-pared with before treatment,TCM syndrome scores in both groups significantly decreased,with a more significant decrease in the observation group compared to the control group(P<0.05).After treatment,triglyceride(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),liver hardness value and fat attenuation value all decreased,while high-density lipoprotein choles-terol(HDL-C),superoxide dismutase(SOD)and glutathione peroxidase(GSH-Px)levels significantly increased in both groups,with the observation group showing better results than the control group(P<0.05).Conclusion:Modified Xiaozhi Qinggan Formu-la based on syndrome differentiation is therapeutically effective in treating MAFLD,which can effectively improve lipid metabolism indicators and antioxidant capacity,and alleviate hepatic fibrosis.

Metabolic-associated fatty liver diseaseXiaozhi Qinggan FormulaModification based on syndrome differentiationLipid metabolismAntioxidant capacityHepatic fibrosisTraditional Chinese medicine symptom scoreClinical efficacy

李偲、卢秉久、于澜、郑佳连、齐兆东

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辽宁中医药大学中医系,沈阳,110031

辽宁中医药大学附属医院肝病科,沈阳,110032

辽宁中医药大学附属第二医院儿科,沈阳,110034

代谢相关脂肪性肝病 消脂清肝方 辨证加减 脂代谢 抗氧化能力 肝纤维化 中医证候积分 临床疗效

辽宁省教育厅科学技术研究项目

1202015

2023

世界中医药
世界中医药学会联合会

世界中医药

CSTPCDCHSSCD北大核心
影响因子:1.266
ISSN:1673-7202
年,卷(期):2023.18(20)
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