首页|黄芪多糖免疫调节和抗肿瘤作用机制研究新进展

黄芪多糖免疫调节和抗肿瘤作用机制研究新进展

Recent Advances in the Study of the Immunomodulatory and Antitumor Mechanisms of Astragalus Polysaccharides

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  • 国家科技期刊平台
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  • NSTL
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黄芪多糖(APS)作为黄芪的主要活性成分,因其在抗肿瘤过程中发挥了重要作用,日益受到关注.肿瘤相关中性粒细胞(TANs)在肿瘤的发生发展中的促瘤和抑瘤作用,已成为肿瘤学研究领域的热点.通过查询并总结APS 对TANs抗肿瘤作用的促进及促肿瘤作用的抑制两方面的作用机制,对其相关研究进行综述,就抑制血管生产、蛋白质的水解、相关细胞因子的表达、调控细胞周期与细胞凋亡过程等方面进行分析,总结了相关中草药促进TANs发挥抗肿瘤作用的研究进展,为进一步明晰其相关的作用机制及发展现状提供理论支持.
Astragalus polysaccharides(APS),as the main active component of Astragalus,has attracted increasing attention be-cause of its important role in anti-tumor process.The dual roles of tumor-associated neutrophils(TANs)in promoting and inhibiting tumorigenesis and development has become a hotspot in the field of oncology research.By investigating and summarizing the dual roles of APS in promoting the anti-tumor effects of TANs and inhibiting the pro-tumor effects,this paper reviewed the related litera-tures,analyzed the mechanisms of inhibiting angiogenesis,protein hydrolysis,regulating the expression of relevant cytokines,modu-lating the cell cycle and apoptosis processes,and outlines the research progress of related traditional Chinese herbs in promoting the anti-tumor effects of TANs,providing theoretical support for further clarifying its relevant mechanisms and development status.

AstragalusAstragalus PolysaccharidesImmunomodulationTumor-Associated NeutrophilsAnti-tumorTumor Cell ApoptosisReview

虞跃跃、俞瑶帅、汪铱宇、崔建美、孙欢、孟成鑫、李云霞、朱延继

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华北理工大学中医学院,河北,063210

河北中医学院第一附属医院,石家庄,050091

黄芪 黄芪多糖 免疫调节 肿瘤相关中性粒细胞 抗肿瘤 肿瘤细胞凋亡 综述

国家科技部对发展中国家科技援助项目河北省中医药联合基金重点项目国家级大学生创新创业训练计划项目河北省省属高校基本科研业务费项目唐山市科技创新团队培养计划项目

KY201904005H2022209068X2020012JQN202103418130204B

2023

10.3969/j.issn.1673-7202.2023.20.026

世界中医药
世界中医药学会联合会

世界中医药

CSTPCDCHSSCD北大核心
影响因子：1.266
ISSN：1673-7202
年,卷(期)：2023.18(20)
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