肠道菌群对慢性疲劳综合征中枢神经系统的调控机制
Mechanism of Intestinal Flora Regulating the Central Nervous System of Patients with Chronic Fatigue Syndrome
顾元嘉 1谢芳芳 1管翀 1王桂茂 2成子己 1张帅攀 1郭光昕 1姚斐3
作者信息
- 1. 上海中医药大学针灸推拿学院,上海,201203
- 2. 上海中医药大学附属市中医医院,上海,200071
- 3. 上海中医药大学针灸推拿学院,上海,201203;上海中医药大学附属市中医医院,上海,200071
- 折叠
摘要
慢性疲劳综合征(CFS)是以长时间无法解释的疲劳、睡眠后精力无法自行恢复为主要特征的神经免疫疾病.肠道菌群作为调节中枢神经系统的关键因素,参与CFS的发生发展.为明确肠道菌群在CFS发病过程的作用机制.现基于微生物-肠-脑轴,分析影响CFS的肠道菌群及其代谢产物,探讨肠道菌群失调减弱内毒素耐受、破坏肠道屏障、改变肠道菌群代谢进而调控CFS中枢神经系统的内在机制.为进一步开展CFS肠道微生物研究提供参考,同时为CFS的防治提供新的临床思路.
Abstract
Chronic fatigue syndrome(CFS)is a neuroimmune disease characterized by unexplained fatigue for a long time and ina-bility to recover energy after sleep.As a key factor regulating the central nervous system,intestinal flora participates in the occur-rence and development of CFS.To clarify the mechanism of intestinal flora in the pathogenesis of CFS,this paper analyzed the intes-tinal flora and its metabolites affecting CFS based on the microorganism-gut-brain axis,and discussed the internal mechanism of in-testinal flora imbalance in weakening endotoxin tolerance,destroying intestinal barrier,changing intestinal flora metabolism to regu-late the central nervous system of CFS.The paper facilitates the further research on intestinal microorganisms of CFS patients and provide a new clinical idea for the prevention and treatment of CFS.
关键词
肠道菌群/慢性疲劳综合征/微生物-肠-脑轴/中枢神经系统/肠道屏障/内毒素耐受/神经炎症Key words
Intestinal flora/Chronic fatigue syndrome/Microorganism-gut-brain axis/Central nervous system/Intestinal barrier/Endotoxin tolerance/Neuritis引用本文复制引用
基金项目
国家自然科学基金面上项目(81774443)
出版年
2023
国家科技期刊平台
NSTL
维普
万方数据