基于结直肠癌发病机制的中医药防治效应靶点
Effective Therapeutic Targets of Traditional Chinese Medicine for Colorectal Cancer Based on Its Pathogenesis
陈雪 1何善泉 1李卫东2
作者信息
- 1. 中国中医科学院广安门医院,北京,100053
- 2. 中国中医科学院广安门医院科研处,北京,100053
- 折叠
摘要
结直肠癌是常见的恶性肿瘤之一,目前主要采用放疗或化疗的治疗方案,虽然能在一定程度上缓解患者的症状,但是治疗过程产生的不良反应严重影响了疗效的发挥.中医药在防治结直肠癌方面具有疗效确切和安全性高的优势,是结直肠癌防治的补充替代疗法.笔者将肠癌的发病机制作为切入点,从基因突变、信号通路调控异常、炎性微环境等3方面对中医药防治肠癌的可能作用靶点进行系统总结,归纳出Wnt/β-catenin信号通路、单磷酸腺苷活化蛋白激酶(AMPK)、Stat3基因、丝裂原活化蛋白激酶(MAPK)、P53基因等主要作用靶点,以期进一步为临床中医药防治肠癌和有效药物的研发提供思路和线索.
Abstract
Colorectal cancer(CRC)is one of the common malignant tumors.Currently,radiotherapy or chemotherapy is the main treatment scheme,which can alleviate patients'symptoms to a certain extent,but the adverse effects during the treatment process seriously affect the efficacy of the treatment.Traditional Chinese medicine(TCM)is a complementary alternative therapy for the prevention and treatment of CRC,which has the advantages of precise efficacy and high safety.Starting from the pathogenesis of in-testinal cancer,this paper systematically summarized the possible targets of TCM in the prevention and treatment of CRC from three aspects:gene mutation,abnormal regulation of signaling pathways,and inflammatory microenvironment,and it found the main targets such as Wnt/β-catenin,AMPK,Stat3 gene,MAPK,and P53 gene,so as to further provide ideas and clues for the prevention and treatment of intestinal cancer in clinical TCM and the development of effective drugs.
关键词
肠癌/中医约/防治/靶点/基因突变/信号通路/炎性微环境/作用机制Key words
Intestinal cancer/Traditional Chinese medicine/Prevention and treatment/Targets/Gene mutation/Signaling path-way/Inflammatory microenvironment/Function mechanism引用本文复制引用
基金项目
国家自然科学基金面上项目(82174464)
中国中医科学院科技创新工程重大攻关项目(CI2021A01806)
出版年
2023
国家科技期刊平台
NSTL
维普
万方数据