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微生物-脑-肠轴与脑卒中后抑郁的研究进展

Research Grogress of Microbiota-gut-brain Axis and Post-stroke Depression

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脑卒中后抑郁(PSD)是指发生于脑卒中后,表现出脑卒中症状以外的一系列以情绪低落、兴趣缺失为主要特征的情感障碍综合征,常伴有躯体症状.微生物-脑-肠轴是指中枢神经系统和胃肠道之间持续的双向沟通,微生物-脑-肠轴之间的相互作用可能在脑卒中后抑郁的发病机制中发挥作用.现结合国内外的研究进展,就微生物-脑-肠轴在脑卒中后抑郁中的主要作用进行探讨,以期为脑卒中后抑郁的治疗提供新思路.
Post-stroke depression(PSD)refers to a series of emotional disorder syndromes characterized by depression and lack of interest except for the symptoms of stroke,and it is often accompanied by physical symptoms.Microbiota-gut-brain axis refers to the continuous two-way communication between the central nervous system and the gastrointestinal tract.The interaction in the microbi-ota-gut-brain axis may play a role in the pathogenesis of PSD.Therefore,combined with the research progress in China and abroad,this paper discussed the main role of microbiota-gut-brain axis in PSD,so as to provide new ideas for the treatment of PSD.

MicrobiotaPSDMicrobiota-gut-brain axisIntestinal floraProbioticsFecal transplantation

许慧、李恋秋、周鑫、刘辉、叶海敏

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湖南中医药大学,长沙,410208

湖南中医药大学第二附属医院,长沙,410005

微生物 脑卒中后抑郁 微生物-脑-肠轴 肠道菌群 益生菌 粪便移植

湖南省自然科学基金湖南中医药大学校级科研基金

2021JJ305192020XJJJ056

2023

世界中医药
世界中医药学会联合会

世界中医药

CSTPCDCHSSCD北大核心
影响因子:1.266
ISSN:1673-7202
年,卷(期):2023.18(21)
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