微生物-脑-肠轴与脑卒中后抑郁的研究进展
Research Grogress of Microbiota-gut-brain Axis and Post-stroke Depression
许慧 1李恋秋 1周鑫 1刘辉 1叶海敏2
作者信息
- 1. 湖南中医药大学,长沙,410208
- 2. 湖南中医药大学第二附属医院,长沙,410005
- 折叠
摘要
脑卒中后抑郁(PSD)是指发生于脑卒中后,表现出脑卒中症状以外的一系列以情绪低落、兴趣缺失为主要特征的情感障碍综合征,常伴有躯体症状.微生物-脑-肠轴是指中枢神经系统和胃肠道之间持续的双向沟通,微生物-脑-肠轴之间的相互作用可能在脑卒中后抑郁的发病机制中发挥作用.现结合国内外的研究进展,就微生物-脑-肠轴在脑卒中后抑郁中的主要作用进行探讨,以期为脑卒中后抑郁的治疗提供新思路.
Abstract
Post-stroke depression(PSD)refers to a series of emotional disorder syndromes characterized by depression and lack of interest except for the symptoms of stroke,and it is often accompanied by physical symptoms.Microbiota-gut-brain axis refers to the continuous two-way communication between the central nervous system and the gastrointestinal tract.The interaction in the microbi-ota-gut-brain axis may play a role in the pathogenesis of PSD.Therefore,combined with the research progress in China and abroad,this paper discussed the main role of microbiota-gut-brain axis in PSD,so as to provide new ideas for the treatment of PSD.
关键词
微生物/脑卒中后抑郁/微生物-脑-肠轴/肠道菌群/益生菌/粪便移植Key words
Microbiota/PSD/Microbiota-gut-brain axis/Intestinal flora/Probiotics/Fecal transplantation引用本文复制引用
基金项目
湖南省自然科学基金(2021JJ30519)
湖南中医药大学校级科研基金(2020XJJJ056)
出版年
2023
国家科技期刊平台
NSTL
维普
万方数据