乳核散结片抗炎镇痛的药理实验研究
Pharmacological Study of Ruhe Sanjie Tablet for Anti-inflammation and Analgesia
黄秋凌 1郑明翠 2宁娜1
作者信息
- 1. 广州白云山中一药业有限公司,广州,510530
- 2. 广州白云山奇星药业有限公司,广州,510530
- 折叠
摘要
目的:探讨乳核散结片的抗炎及镇痛作用.方法:用SD大鼠棉球肉芽肿实验和二甲苯致小鼠毛细血管通透性增加实验,观察乳核散结片的抗炎作用;同时建立冰醋酸致小鼠扭体实验,观察乳核散结片的止痛作用.结果:乳核散结片低、中、高剂量组均能显著抑制大鼠肉芽增生,与空白对照组比较,差异均有统计学意义(均P＜0.05),其抑制率分别为30.0％、47.4％、53.6％,且呈量效关系.乳核散结片低、中、高剂量组均能有效降低小鼠毛细血管通透性,蓝斑光密度(OD)值与同期空白对照组比较,差异均有统计学意义(均P＜0.001),其对毛细血管通透性抑制率分别为47.6％、55.0％、65.2％,并呈量效关系.乳核散结片低、中、高剂量组均能有效减少冰醋酸致小鼠扭体次数(P＜0.001),其镇痛抑制率分别为34.2％、42.0％、51.5％,呈量效关系.结论:乳核散结片药理实验研究表明其具有抗炎及镇痛作用.
Abstract
Objective:To investigate the anti-inflammatory and analgesic effects of Ruhe Sanjie Tablet.Methods:Cotton pellet-in-duced granuloma formation of Sprague Dawley(SD)rats and the increase in capillary permeability of mice induced by xylene were used to observe the anti-inflammatory effect of Ruhe Sanjie Tablet.The acetic acid writhing experiment in mice was established to observe the analgesic effect of the prescription.Results:The low-,medium-and high-dose Ruhe Sanjie Tablet inhibited the prolifera-tion of rat granulation tissue,and there were differences compared with the blank control group(all P＜0.05).The inhibition rates of the three doses were 30.0％,47.4％and 53.6％,respectively,showing a dose-effect relationship.Ruhe Sanjie Tablet at low,medium and high doses reduced the capillary permeability of mice,and the optical density(OD)was lower than that in the blank control group(all P＜0.001).The inhibition rates of capillary permeability were 47.6％,55.0％and 65.2％,respectively,with a dose-effect relationship.Ruhe Sanjie Tablet at each dose lowered the number of writhing induced by acetic acid in mice(P＜0.001),and the analgesic inhibition rates at low,medium and high dose were 34.2％,42.0％and 51.5％,respectively,presenting a dose-effect relationship.Conclusion:Pharmacological studies of Ruhe Sanjie Tablet indicates that it has anti-inflammatory and analgesic effects.
关键词
乳核散结片/抗炎/镇痛/疗效/药理实验/毛细血管通透性/结缔组织增生/乳癖消Key words
Ruhe Sanjie Tablet/Anti-inflammation/Analgesia/Curative effect/Pharmacological study/Capillary permeability/Connective tissue hyperplasia/Rupixiao引用本文复制引用
基金项目
广东省重点领域研发计划(2020B1111110004)
出版年
2023
国家科技期刊平台
NSTL
维普
万方数据