Objective:To investigate the anti-inflammatory and analgesic effects of Ruhe Sanjie Tablet.Methods:Cotton pellet-in-duced granuloma formation of Sprague Dawley(SD)rats and the increase in capillary permeability of mice induced by xylene were used to observe the anti-inflammatory effect of Ruhe Sanjie Tablet.The acetic acid writhing experiment in mice was established to observe the analgesic effect of the prescription.Results:The low-,medium-and high-dose Ruhe Sanjie Tablet inhibited the prolifera-tion of rat granulation tissue,and there were differences compared with the blank control group(all P＜0.05).The inhibition rates of the three doses were 30.0％,47.4％and 53.6％,respectively,showing a dose-effect relationship.Ruhe Sanjie Tablet at low,medium and high doses reduced the capillary permeability of mice,and the optical density(OD)was lower than that in the blank control group(all P＜0.001).The inhibition rates of capillary permeability were 47.6％,55.0％and 65.2％,respectively,with a dose-effect relationship.Ruhe Sanjie Tablet at each dose lowered the number of writhing induced by acetic acid in mice(P＜0.001),and the analgesic inhibition rates at low,medium and high dose were 34.2％,42.0％and 51.5％,respectively,presenting a dose-effect relationship.Conclusion:Pharmacological studies of Ruhe Sanjie Tablet indicates that it has anti-inflammatory and analgesic effects.
国家科技期刊平台
NSTL
维普
万方数据
