衰老视角阐释膝骨关节炎虚实夹杂病机的科学内涵

Scientific Connotation of Pathogenesis with Mixed Deficiency and Excess of Knee Osteoarthritis from Senescence Perspective

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中文摘要：膝骨关节炎是骨伤科常见的退行性疾病,症状以膝关节疼痛、肿胀、活动受限为主.既往中医并无关节炎病名,对此病的认识多依据症状,早期归入"痹证""膝痹",后期归入"痿证"范畴.病因病机方面总体认为本病属于本虚标实,本虚主要是肝肾不足、气血亏虚,标实主要是气血痹阻、寒凝痰结等.因此,在治法方面,各家经验虽然治法、用药不一,但多数强调治法的攻补兼施.膝骨关节炎本质上是骨关节的衰老,结合中医对于衰老的认识,以及现代医学对于组织细胞衰老的认识,从细胞衰老及其在组织间扩散的机制认识膝骨关节炎"虚实夹杂"的科学内涵,对临床和科研具有启发性意义.

外文摘要：Knee osteoarthritis is a common degenerative disease in orthopedics.The symptoms are mainly knee-joint pain,swell-ing,and limited movement.In the past,there was no name for arthritis in traditional Chinese medicine.The understanding of arthri-tis was based on symptoms,which were classified as arthralgia syndrome and paralysis syndrome in the early stage and impotence syndrome in the later stage.In terms of etiology and pathogenesis,it is generally considered that this disease is characterized by a deficiency of the liver and kidney and deficiency of qi and blood in origin and by obstruction of qi and blood,cold coagulation,and phlegm accumulation in superficiality.Therefore,for the treatment,although doctors have different treatment and drug use methods,most of them emphasize the combination of tonification and purgation.Knee osteoarthritis essentially reflects the senescence of bone and joints.By combining the understanding of senescence in traditional Chinese medicine and the understanding of tissue cell se-nescence in modern medicine,it is instructive for clinical and scientific research to understand the scientific connotation of mixed deficiency and excess in knee osteoarthritis from the mechanism of cell senescence and its diffusion in tissue.

外文关键词：

Knee osteoarthritisKnee paralysisDegenerative diseaseMixed deficiency and excessPathogenesisCell senes-cenceScientific connotationPrevention and treatment

作者：

邢润麟、廖太阳、王培民

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作者单位：

南京中医药大学附属医院/江苏省中医院,南京,210029

关键词：

膝骨关节炎膝痹退行性疾病虚实夹杂病机学细胞衰老科学内涵防治

基金：

国家自然科学基金青年科学基金江苏省中医院高峰人才项目南京中医药大学自然科学基金

项目编号：

81804123y2021rc39XZR2020005

出版年：

2023

DOI：

10.3969/j.issn.1673-7202.2023.23.011

世界中医药

世界中医药学会联合会

世界中医药

CSTPCDCHSSCD北大核心

影响因子：1.266

ISSN：1673-7202

年,卷(期)：2023.18(23)

参考文献量16