干燥方式对麦门冬汤浸膏粉超高效液相色谱及物理指纹图谱的影响

Effect of Drying Method on Ultra High Performance Liquid Chromatography and Physical Fingerprint of the Extract Powder of Maimendong Decoction

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中文摘要：目的:考察不同干燥方式对麦门冬汤浸膏粉超高效液相色谱(UPLC)及物理指纹图谱的影响.方法:分别采用喷雾干燥、真空干燥、鼓风干燥、冷冻干燥4种干燥方式制备麦门冬汤浸膏粉,建立UPLC指纹图谱,并以5个一级指标和9个二级指标构建物理指纹图谱,采用相似度评价、聚类分析和主成分分析分别比较UPLC指纹图谱和物理指纹图谱的差异,通过计算可压性参数比较4种麦门冬汤浸膏粉的压缩成型性.结果:4种麦门冬汤浸膏粉的UPLC指纹图谱相似度均大于0.95,物理指纹图谱的相似度分别为0.955、0.888、0.987、0.941;UPLC指纹图谱和物理指纹图谱的聚类分析均将4种麦门冬汤浸膏粉分为2类;主成分分析分别提取出3个和2个主成分,分别包含了原始数据100％和90.03％的信息;喷雾干燥粉的压缩成型性最优.结论:不同干燥方式对麦门冬汤浸膏粉的UPLC指纹图谱影响不大,对其物理指纹图谱影响较明显.

外文摘要：Objective:To investigate the effect of different drying methods on the ultra high performance liquid chromatography(UPLC)and physical fingerprint of the extract powder of Maimendong Decoction.Methods:Spray drying,vacuum drying,blast dr-ying,and freeze drying were used to prepare the extract powder of Maimendong Decoction.The UPLC fingerprint was established,and the physical fingerprint was constructed with 5 first-level indicators and 9 second-level indicators.Similarity evaluation,cluster analysis,and principal component analysis were performed to compare the differences between UPLC fingerprint and physical fin-gerprint.The compressibility parameters were calculated to compare the compressibility of the four extract powders of Maimendong Decoction.Results:The UPLC fingerprints of the four extract powders of Maimendong Decoction had the similarity all greater than 0.95,and the similarities of physical fingerprint were 0.955,0.888,0.987,and 0.941,respectively.The cluster analysis of UPLC fingerprint and physical fingerprint were both consistent,which divided the four extract powders of Maimendong Decoction into two categories,and three and two principal components were obtained from the principal component analysis,respectively,which con-tained 100％and 90.03％of the original data,respectively.The spray-dried powder had the optimal compressibility.Conclusion:Different drying methods had little effect on the UPLC fingerprint of the extract powder of Maimendong Decoction,but exerted a sig-nificant effect on its physical fingerprint.

外文关键词：

Extract powder of Maimendong DecoctionDrying methodUltra-high performance liquid chromatography(UPLC)Finger-printPhysical fingerprintSpray dryingVacuum dryingBlast dryingFreeze drying

作者：

施文婷、王寿富、邓桂海、李玲、杨赞、王瑜婷、孙冬梅

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作者单位：

广东一方制药有限公司,广东省中药配方颗粒企业重点实验室,佛山,528244

关键词：

麦门冬汤浸膏粉干燥方式超高效液相色谱指纹图谱物理指纹图谱喷雾干燥真空干燥鼓风干燥冷冻干燥

基金：

国家科技重大专项"重大新药创制"

项目编号：

2018ZX09721005-007-009

出版年：

2023

DOI：

10.3969/j.issn.1673-7202.2023.24.002

世界中医药

世界中医药学会联合会

世界中医药

CSTPCDCHSSCD北大核心

影响因子：1.266

ISSN：1673-7202

年,卷(期)：2023.18(24)

参考文献量18