Objective:To explore the feasibility of an improved three-chamber social device to evaluate the degree of animal social preference.Methods:Attention deficit hyperactivity disorder(ADHD)rats were used as social disorder model animals,and Wistar-Kyoto(WKY)rats and Wistar rats were used as control group.The model group received Xiaoer Huanglong granules,a commonly used clinical traditional Chinese medicine for ADHD,at doses of 1.88 g/kg and 3.75 g/kg via gavage for 16 days.An improved three-chamber social apparatus was employed,and the time,frequency,distance and proportion of rats in the area with close com-munication and the area with unfamiliar rat side were used as behavioral indicators to test the feasibility of this method for evalua-ting social behavior.Results:Compared with the Wistar rat group,the rats in the model group and the WKY rat group showed a sig-nificant decrease in the time spent in the close interaction area and the unfamiliar rat side area(P＜0.01).Other indicators,such as frequency,distance and proportion,were also reduced to varying degrees.Both high and low doses of Xiaoer huanglong granules increased the values of these indicators in the model rats.Conclusion:This method can accurately capture the social behavior char-acteristics of animals,enabling a comprehensive and objective evaluation of animal social preference.
维普
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