Objective:To study the modeling characteristics and index characteristics of benign prostatic hyperplasia in rats,and to provide reference and basis for the improvement of the efficiency of experimental modeling and scientific evaluation of drug preven-tion and treatment.Methods:A total of 228 literatures on animal models of benign prostatic hyperplasia in rats from January 2001 to February 2023 were collected from the China National Knowledge Infrastructure(CNKI)database.The information of animal type,modeling drug,positive control drug,test drug,drug administration time,dosage,administration method and site,evaluation in-dex and test index were recorded and analyzed.Results:It is recommended to select SD male rats.The modeling scheme is to re-move the bilateral testes of rats and inject testosterone propionate 3 to 5 mg/kg intraperitoneally for 30 days,once a day.Common indicators include tissue biochemical indicators,serum biochemical indicators,prostate histopathological indicators,and so on.Fin-asteride is the main therapeutic drug.The commonly used traditional Chinese medicine compounds are Xianjia decoction,Longchang capsule and Jiawei Guizhi Fuling granule.The administration period is about 30 days.Conclusion:Through analysis and discus-sion,it can be concluded that the efficient and accurate modeling method is of significance for the modeling and treatment of benign prostatic hyperplasia in animals.
关键词
前列腺增生/动物模型/造模特点/中医药防治/数据挖掘/指标特征/综述/模型研究
Key words
Prostatic hyperplasia/Animal model/Modeling characteristics/Prevention and treatment with traditional Chinese medicine/Data mining/Index characteristics/Review/Model research
维普
万方数据