Effects of Kidney-tonifying Herbs on Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells from the Perspective of m6A Modification
Bone marrow mesenchymal stem cells(BMSCs)are adult stem cells with osteogenic differentiation ability.The weake-ning osteogenic differentiation ability of BMSCs can easily lead to a variety of bone-related diseases,such as osteoporosis.Based on the theory of traditional Chinese medicine that"kidney governs the bone and generates the marrow",kidney-tonifying herbs are commonly used in the treatment of osteoporosis,which has the effect of regulating osteogenic differentiation of BMSCs.N6-methylad-enosine(m6A)is a post-transcriptional modification of eukaryotic RNA and a key factor in osteogenic differentiation of BMSCs.This study explores the relationship between m6A dynamic modification and osteogenic differentiation of BMSCs,and analyzes the possible role and targets of kidney-tonifying herbs in regulating m6A modification,which can provide new targets for kidney-tonify-ing herbs in the treatment of osteoporosis,and provide ideas for the scientific interpretation of the theory of visceral manifestation of kidney in traditional Chinese medicine.
Bone marrow mesenchymal stem cellsm6A modificationKidney-tonifying herbsOsteogenic differentiationOsteo-porosisTargetMechanismVisceral manifestation of kidney
万方数据
维普
