Bone marrow mesenchymal stem cells(BMSCs)are adult stem cells with osteogenic differentiation ability.The weake-ning osteogenic differentiation ability of BMSCs can easily lead to a variety of bone-related diseases,such as osteoporosis.Based on the theory of traditional Chinese medicine that"kidney governs the bone and generates the marrow",kidney-tonifying herbs are commonly used in the treatment of osteoporosis,which has the effect of regulating osteogenic differentiation of BMSCs.N6-methylad-enosine(m6A)is a post-transcriptional modification of eukaryotic RNA and a key factor in osteogenic differentiation of BMSCs.This study explores the relationship between m6A dynamic modification and osteogenic differentiation of BMSCs,and analyzes the possible role and targets of kidney-tonifying herbs in regulating m6A modification,which can provide new targets for kidney-tonify-ing herbs in the treatment of osteoporosis,and provide ideas for the scientific interpretation of the theory of visceral manifestation of kidney in traditional Chinese medicine.
关键词
骨间充质干细胞/N6甲基腺苷修饰/补肾中药/成骨分化/骨质疏松/靶点/作用机制/肾藏象
Key words
Bone marrow mesenchymal stem cells/m6A modification/Kidney-tonifying herbs/Osteogenic differentiation/Osteo-porosis/Target/Mechanism/Visceral manifestation of kidney
维普
万方数据