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参仙升脉口服液中挥发性成分及无机元素研究

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目的:利用挥发性物质的定性鉴别和无机元素的定量分析,探究参仙升脉口服液的化学物质基础.方法:采用顶空气相色谱-质谱联用(HS-GC-MS)分析技术,通过质谱信息,搜索美国国家标准与技术研究院(NIST)数据库,并结合相关文献资料,对参仙升脉口服液中的挥发性化学成分进行快速辨识;并利用电感耦合等离子体质谱(ICP-MS)分析技术对参仙升脉口服液中的21种无机元素进行定量分析.结果:从参仙升脉口服液中共检测到29个挥发性成分,这些成分主要归属于组方药材细辛,相对含量较高的成分有11个,占所鉴定挥发性成分总量的82.64％.无机元素定量分析结果显示,参仙升脉口服液中含有丰富的人体必需常量元素Na、Mg和K,以及较高水平的Fe、Zn、Mn微量元素;重金属及有害元素Cd、Pb、As、Hg、Cu的含量均符合相关限度要求.结论:阐明了参仙升脉口服液中的挥发性化学物质基础和无机元素的种类及含量,为其药效物质基础的研究和质量控制提供了依据.
Volatile Components and Inorganic Elements in Shenxian Shengmai Oral Liquid
Objective:To explore the chemical basis of Shenxian Shengmai Oral Liquid using qualitative identification of volatile components and quantitative analysis of inorganic elements.Methods:Headspace gas chromatography-mass spectrometry(HS-GC-MS)analysis technology was employed to identify the volatile chemical components in Shenxian Shengmai Oral Liquid based on mass spectrometry information by searching the National Institute of Standards and Technology(NIST)database and referring to rel-evant literature.Additionally,inductively coupled plasma mass spectrometry(ICP-MS)analysis technology was utilized for the quantitative analysis of 21 inorganic elements in Shenxian Shengmai Oral Liquid.Results:A total of 29 volatile components were detected in Shenxian Shengmai Oral Liquid,mainly attributed to Asari Radix et Rhizoma in the formula.Among them,11 compo-nents with relatively high content accounted for 82.64％of the total identified volatile components.The quantitative analysis of in-organic elements revealed that Shenxian Shengmai Oral Liquid contained abundant essential elements for the human body,such as Na,Mg,and K,as well as elevated levels of trace elements Fe,Zn,and Mn.The content of heavy metals and harmful elements,in-cluding Cd,Pb,As,Hg,and Cu,all met the relevant limit requirements.Conclusion:The volatile chemical components and inorgan-ic elements in Shenxian Shengmai Oral Liquid were elucidated,providing a basis for the study of its pharmacological substance foundation and quality control.

Shenxian Shengmai Oral LiquidHS-GC-MSICP-MSVolatile chemical constituentsInorganic elementsMaterial basisQuality control

宗时宇、黄壮壮、张红、李晔、刘峰、刘洋

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陕西省中医药研究院中药研究所,西安,710003

陕西步长制药有限公司,西安,710075

参仙升脉口服液 顶空气相色谱质谱联用 电感耦合等离子体质谱 挥发性化学成分 无机元素 物质基础 质量控制

"重大新药创制"科技重大专项陕西省自然科学基础研究计划项目陕西省重点研发计划-重点产业创新链项目陕西省创新能力支撑计划项目

2018ZX09721005-004-0072020JQ-9872021ZDLSF04-062019KJXX-020

2024

10.3969/j.issn.1673-7202.2024.03.003

世界中医药
世界中医药学会联合会

世界中医药

CSTPCDCHSSCD北大核心
影响因子：1.266
ISSN：1673-7202
年,卷(期)：2024.19(3)
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