Effects of Guizhi Fuling Capsules on Recovery and Inflammatory Mediators in Patients with Early Endometrial Cancer after Laparoscopy
Objective:To observe the effects of Guizhi Fuling Capsules on the postoperative recovery and levels of inflammatory mediators in patients with early endometrial cancer after laparoscopy.Methods:Eighty patients with early endometrial cancer trea-ted at Xuzhou Central Hospital from June 2019 to May 2022 were enrolled and randomly divided into an observation group and a control group,with 40 cases in each group.The control group received laparoscopy,while the observation group received postopera-tive treatment with Guizhi Fuling Capsules,3 capsules per time,3 times a day,taken orally after meals for 3 months.The disease re-mission rate,postoperative recovery[Visual Analogue Scale(VAS)scores at 1,3,and 7 days postoperatively,bladder function re-covery time,and length of hospital stay],traditional Chinese medicine(TCM)syndrome scores,and related serum indicators[canc-er antigen(CA)125,human epididymis protein 4(HE4),interleukin-4(IL-4),and IL-6]before surgery and 3 months after surger-y,as well as the incidence of postoperative complications,were compared between the two groups.Results:The total disease remis-sion rate in the observation group was 90.00％,higher than that in the control group(72.50％)(P＜0.05).The VAS scores at 3 and 7 days postoperatively were lower in the observation group than in the control group,and the bladder function recovery time and length of hospital stay were shorter in the observation group(all P＜0.05).Three months after surgery,the TCM syndrome scores in the observation group were lower than those in the control group(all P＜0.05),and the serum levels of CA125,HE4,and IL-6 were lower in the observation group(all P＜0.05),while the IL-4 level was higher than that in the control group(P＜0.05).There was no significant difference in the incidence of postoperative complications between the two groups(P＞0.05).Conclusion:Guizhi Fuling Capsules can effectively reduce levels of tumor markers and inflammatory mediators in patients with early endometrial cancer after laparoscopy,promote postoperative recovery,and improve the clinical remission rate.
万方数据
维普
