Lung cancer is a malignant tumor with persistently high incidence and mortality rates worldwide,posing a serious threat to people's lives and health.Modern medicine has undergone three major transformations in the treatment of lung cancer,i.e.,tra-ditional chemotherapy and radiotherapy,precision targeted therapy,and immunotherapy.Among them,immunotherapy mainly relies on the adaptive immune system to monitor and kill tumor cells.The currently popular chimeric antigen receptor T cell immunothera-py enhances the ability of T cells to target and kill tumor cells,achieving the goal of anticancer treatment.Immunocytes are part of the tumor microenvironment(TME),indicating that intervening in the TME has become a focus of cancer treatment.TME can be speculated based on analogies from traditional Chinese medicine(TCM),and its pathogenesis is summarized as follows:immune e-vasion is similar to the disharmony between nutrient and defensive qi and insecurity of lung-defensive qi;hypoxic microenvironment is similar to qi deficiency of lung,spleen,and kidney;acidic microenvironment is similar to phlegm-dampness obstructing the lungs;inflammatory microenvironment is similar to accumulation of phlegm,blood stasis,and cancer toxin.It suggests that by alig-ning lung cancer TME with TCM pathogenesis,this study can provide a reference for the selection of TCM treatment for lung cancer.
关键词
肺癌/免疫逃逸/酸性微环境/炎性微环境/中医病机/营卫失和/肺脾肾气虚/痰瘀癌毒积聚
Key words
Lung cancer/Immune evasion/Acidic microenvironment/Inflammatory microenvironment/Pathogenesis of TCM/Disharmony between nutrient and defensive qi/Qi deficiency of lung,spleen,and kidney/Accumulation of phlegm,blood stasis,and cancer toxin
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