Gout disease is a progressive metabolism disease,which is closely associated with hyperuricemia,urate crystal deposi-tion in the joint or kidney,and other uric acid metabolism disorders.According to the pathological progression and clinical manifes-tations,gout disease can be divided into different stages,including hyperuricemia,urate crystal deposition,and gouty inflammation.ATP binding cassette subfamily G member 2(ABCG2)is a high-throughput uric acid transporter that is involved in mediating uric acid excretion in the intestine and kidney and is closely associated with gouty inflammation.This paper summarized the pathogene-sis of ABCG2-associated gout disease,so as to provide a new point of view into the further research and treatment of gout disease in clinics.
ATP binding cassette subfamily G member 2/Gout disease/Hyperuricemia/Gouty arthritis/Urate crystal deposition/Uric acid metabolism/Pathogenesis/Research progress
维普
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