首页|三磷酸腺苷结合盒转运蛋白G2与痛风病关联的病理机制研究进展

三磷酸腺苷结合盒转运蛋白G2与痛风病关联的病理机制研究进展

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痛风病是指与高尿酸血症、尿酸盐沉积(关节、肾脏)等尿酸代谢紊乱密切相关的进展性代谢疾病,根据其病理进展特点和临床表现,其病程可分为高尿酸血症阶段、尿酸盐沉积阶段、痛风性炎症阶段.三磷酸腺苷结合盒转运蛋白G2(ABCG2)是高通量的尿酸转运体,既参与了机体尿酸外排的肠-肾途径,又与痛风性炎症密切相关.通过切入ABCG2,对痛风病病理机制研究进展进行综述,以期为临床痛风病的深入研究及防治提供新的见解.
Research Progress of Association between ABCG2 and Gout Disease in Pathogenesis
Gout disease is a progressive metabolism disease,which is closely associated with hyperuricemia,urate crystal deposi-tion in the joint or kidney,and other uric acid metabolism disorders.According to the pathological progression and clinical manifes-tations,gout disease can be divided into different stages,including hyperuricemia,urate crystal deposition,and gouty inflammation.ATP binding cassette subfamily G member 2(ABCG2)is a high-throughput uric acid transporter that is involved in mediating uric acid excretion in the intestine and kidney and is closely associated with gouty inflammation.This paper summarized the pathogene-sis of ABCG2-associated gout disease,so as to provide a new point of view into the further research and treatment of gout disease in clinics.

ATP binding cassette subfamily G member 2Gout diseaseHyperuricemiaGouty arthritisUrate crystal depositionUric acid metabolismPathogenesisResearch progress

韩宇、黄锦坚、林志健、张冰、王雨

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北京中医药大学中药学院,北京,102488

三磷酸腺苷结合盒转运蛋白G2 痛风病 高尿酸血症 痛风性关节炎 尿酸盐沉积 尿酸代谢 病理机制 研究进展

国家自然科学基金青年科学基金项目国家自然科学基金项目

82104475U20A20406

2024

10.3969/j.issn.1673-7202.2024.03.024

世界中医药
世界中医药学会联合会

世界中医药

CSTPCDCHSSCD北大核心
影响因子：1.266
ISSN：1673-7202
年,卷(期)：2024.19(3)
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