Pharmacokinetics of Classic Tibetan Medicine-ruyi Zhenbao Tablets after Repeated Administration
Objective:To explore the pharmacokinetics characteristics of Ruyi Zhenbao Tablets in the plasma,a classic Tibetan medicine,after repeated administration,so as to provide a reference and basis for clinical application.Methods:Six male and six fe-male SD rats were divided into the control group and the administration group.They were administered for seven days.Blood sam-ples were collected from their eyes at 0 min before the last administration and 0.25,0.5,0.75,1,2,4,8,24,and 48 h after the ad-ministration,and the pharmacokinetic parameters of agarotetrol,isoliquiritigenin,piperine,and ferulic acid in the plasma were deter-mined.Results:Most of the peak time of the pharmacokinetics parameters of agarotetrol,isoliquiritigenin,piperine,and ferulic acid in the plasma were 1 to 8 h,0.25 h,0.25 to 8 h,and 0.25 h respectively.Cmax was 140±53.9,8.31±6.34,33.4±22.2,and 15.7±7.90 ng/mL,respectively.t1/2 was 10.1±3.85,8.51±4.23,4.45±1.35,and 67.3±55.1 h,respectively.AUC0-t was 1 890±1 440,45.6±14.3,288±150,and 443±165 h × ng/mL,respectively.MRT0-∞ was 13.2±7.45,9.80±4.27,4.91± 1.34,and 103±77.1 h,respectively.The main pharmacokinetics parameters of agarotetrol,isoliquiritigenin,and piperine in rats did not show significant statistical significance(P＞0.05),while the main pharmacokinetics parameters of ferulic acid(Cmax and AUC0-t)showed significant statistical significance(P＜0.05).Conclusion:This study established a research method for the phar-macokinetics of four components,namely agarotetrol,isoliquiritigenin,piperine,and ferulic acid,after repeated administration of Ruyi Zhenbao Tablets and analyzed their pharmacokinetics characteristics to guide the clinical administration cycle and interval.
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