摘要
氧化应激(OS)是指机体遭受各种有害刺激时产生过多的活性氧自由基而无法及时清除,导致氧化系统和抗氧化系统平衡失调,引起组织或细胞功能紊乱和损伤的一种状态.OS与男性不育症(MI)关系密切,OS通过影响精子发生,损伤精子膜、脱氧核糖核酸(DNA)、线粒体,降低精子运动能力,加速细胞凋等途径使精子质量下降,导致MI.研究发现,单味中药的有效成分多糖类化合物(黄芪多糖、党参多糖、枸杞多糖、黄精多糖、山茱萸多糖、当归多糖、女贞子多糖、石斛多糖),黄酮类化合物(菟丝子总黄酮、槲皮素、紫云英苷、羊藿苷、金丝桃苷),皂苷类化合物(人参皂苷、蒺藜皂苷、薯蓣皂苷元),苯丙素类化合物(五味子甲素、姜黄素、白藜芦醇),环烯醚萜苷类化合物(桃叶珊瑚苷),氮苷类化合物(红景天苷),低聚糖类化合物(巴戟甲素),苯乙醇苷类化合物(肉苁蓉苯乙醇苷)多肽类化合物(牡蛎肽)具有抗氧化作用,可提升雄性动物MI模型的生殖功能.
Abstract
Oxidative stress(OS)refers to a state in which the body produces too many reactive oxygen species and free radicals when subjected to various harmful stimuli,which cannot be cleared in a timely manner,leading to an imbalance between the oxida-tive and antioxidant systems and causing dysfunction and damage to tissue or cells.OS is closely related to male infertility(MI).OS reduces sperm quality by affecting spermatogenesis,damaging sperm membranes,deoxyribonucleic acid(DNA),and mitochondria,reducing sperm motility,and accelerating cell apoptosis,leading to MI.This study find that the effective ingredients of single tradi-tional Chinese medicine(TCM)are polysaccharide compounds(astragalus polysaccharide,codonopsis polysaccharide,lycium barba-rum polysaccharide,polygonatum polysaccharide,cornus polysaccharide,angelica polysaccharide,ligustrum lucidum polysaccharide,and dendrobium polysaccharide),flavonoids(total flavonoids of dodder seed,quercetin,shikonin,cablin,and hypericin),saponins(ginsenoside,tribulus terrestris saponin,and diosgenin),phenylpropyl compounds(schisandrin,curcumin,and resveratrol),iridoid glycosides(aucubin),nitrogen glycosides(salidroside),oligosaccharides(Morinda officinalis A),phenylethanol glycosides(pheny-lethanol glycosides of Cistanche deserticola),and polypeptides(oyster peptides),which all have antioxidant effects and can improve the reproductive capacity of MI models of male animals.This provides a certain theoretical basis for the treatment of MI with tradi-tional Chinese medicine.
基金项目
全国老中医药专家学术经验继承工作项目(第七批)(国家中医药管理局国中医药人教函[2022]76号)
江苏省高等学校"青蓝工程"中医药专业群教学团队项目(2021)(苏教师函[2021]11号)
湖北省卫生健康委中医药科研项目(2018-2019)(ZY20190021)
维普
万方数据