Research Progress on Anti-tumor Effect of Traditional Chinese Medicine by Inhibiting HIF-1α-related Signaling Pathways
Hypoxia is a common feature of solid tumors,and the hypoxia microenvironment can cause overexpression of hypoxia in-ducible factor-1(HIF-1).HIF-1α is a key transcriptional regulatory factor in hypoxia response,which is highly expressed in all kinds of tumor tissue.It plays an important role in tumor cell proliferation,invasion and metastasis,angiogenesis,glycolysis,and im-munity and participates in a variety of transduction pathways.Therefore,HIF-1α has a promising prospect as a potential target for the treatment of solid tumors.Compared with HIF-1α inhibitors,with high toxicity and low efficiency,traditional Chinese medicine(TCM)has the advantages of multiple targets,low toxicity,and high tolerance,so it has a wide application prospect in tumor therapy.
HIF-1αTraditional Chinese medicineTumorSignaling pathwayHypoxiaMechanism
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