世界中医药2024，Vol.19Issue(4) ：600-605.DOI:10.3969/j.issn.1673-7202.2024.04.025

中药抑制缺氧诱导因子-1α相关信号通路的抗肿瘤作用研究进展

Research Progress on Anti-tumor Effect of Traditional Chinese Medicine by Inhibiting HIF-1α-related Signaling Pathways

毛梦婷 许尤琪 董孟佳 李伟良 唐杰
世界中医药2024，Vol.19Issue(4) ：600-605.DOI:10.3969/j.issn.1673-7202.2024.04.025
✕
  • 维普
  • 万方数据

中药抑制缺氧诱导因子-1α相关信号通路的抗肿瘤作用研究进展

Research Progress on Anti-tumor Effect of Traditional Chinese Medicine by Inhibiting HIF-1α-related Signaling Pathways

毛梦婷 1许尤琪 2董孟佳 2李伟良 2唐杰2
扫码查看

作者信息

  • 1. 南京中医药大学,南京,210029
  • 2. 南京中医药大学第二附属医院,南京,210017
  • 折叠

摘要

缺氧是实体肿瘤的常见特征,缺氧微环境可引起缺氧诱导因子-1(HIF-1)过表达.HIF-1α是缺氧应答中至关重要的转录调控因子,在各类肿瘤组织中均过表达,其在肿瘤细胞的增殖、侵袭转移、血管生成、糖酵解和免疫中发挥重要作用并参与多种转导通路.因此,HIF-1α作为治疗实体肿瘤的潜在靶点,颇有应用前景.相较于HIF-1α抑制剂存在高毒性、低效性的问题,中药具有多靶点、低毒性、高耐受性等优势,在肿瘤治疗中有广泛的应用前景.

Abstract

Hypoxia is a common feature of solid tumors,and the hypoxia microenvironment can cause overexpression of hypoxia in-ducible factor-1(HIF-1).HIF-1α is a key transcriptional regulatory factor in hypoxia response,which is highly expressed in all kinds of tumor tissue.It plays an important role in tumor cell proliferation,invasion and metastasis,angiogenesis,glycolysis,and im-munity and participates in a variety of transduction pathways.Therefore,HIF-1α has a promising prospect as a potential target for the treatment of solid tumors.Compared with HIF-1α inhibitors,with high toxicity and low efficiency,traditional Chinese medicine(TCM)has the advantages of multiple targets,low toxicity,and high tolerance,so it has a wide application prospect in tumor therapy.

关键词

缺氧诱导因子-1α/中药/肿瘤/信号通路/缺氧/机制

Key words

HIF-1α/Traditional Chinese medicine/Tumor/Signaling pathway/Hypoxia/Mechanism

引用本文复制引用

基金项目

国家自然科学基金(82272671)

江苏省中医药局科技发展计划(YB2020023)

江苏省研究生科研与实践创新计划(SJCX22_0818)

南京中医药大学第二附属医院传承工作室项目()

出版年

2024
世界中医药
世界中医药学会联合会

世界中医药

CSTPCDCHSSCD北大核心
影响因子：1.266
ISSN：1673-7202
参考文献量52
段落导航相关论文