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脑小血管病认知功能障碍的中医药防治研究进展

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脑小血管病认知功能障碍(CSVD-VCI)是在脑小血管病基础上,引起认知功能受损的一类临床综合征.近年来,随着人口老龄化的加速,CSVD-VCI的发病率逐年上升,早诊断早治疗对该病的防治具有重要意义.CSVD-VCI属于中医学健忘、痴呆的范畴,中医学认为其病机涉及虚、痰、瘀、毒等多种因素,可分为脏腑亏虚型、痰瘀阻络型、毒损脑络型等主要证候类型.中医通过辨证论治在该病的治疗中发挥着重要作用,并取得显著进展,本文就CSVD-VCI的病因病机、辨证分型以及近年来中药单药、复方治疗该病的动物实验和临床研究展开综述,为中医药治疗CSVD-VCI提供参考依据.
Research Progress in TCM Prevention and Treatment of Vascular Cognitive Impairment Caused by Cerebral Small Vessel Disease
Vascular cognitive impairment caused by cerebral small vessel disease(CSVD-VCI)is a clinical syndrome of cognitive impairment on the basis of cerebral small vessel disease.As population aging is accelerating in recent years,the incidence of CSVD-VCI is increasing year by year.Early diagnosis and treatment are of great significance to the prevention and treatment of CSVD-VCI.According to the TCM theory,CSVD-VCI is a disease of amnesia and dementia caused by multiple factors including deficien-cy,phlegm,stasis,and toxin.The patients mainly present the syndromes of deficiency in zang-fu organs,phlegm-stasis obstructing collaterals,or toxin damaging brain collateral.TCM plays an important role in the diagnosis and treatment of CSVD-VCI based on syndrome differentiation.Therefore,this paper reviews the research progress in the etiology,pathogenesis,syndrome differentiation of CSVD-VCI as well as the animal experiments and clinical trials about the treatment of this disease with single Chinese medicines and TCM compound prescriptions,aiming to provide a reference for the TCM treatment of CSVD-VCI.

Cerebral small vessel diseaseCognitive impairmentEtiologyPathogenesisSyndromeTreatmentResearch pro-gress

陈雪妍、黄梦妮、秦秀德、江丰、莫嘉欣

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广州中医药大学第四临床医学院,广州,510006

深圳市中医院,深圳,518033

天津中医药大学,天津,301617

广州中医药大学第一临床医学院,广州,510499

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脑小血管病 认知功能障碍 病因 病机 证型 治疗 研究进展

国家自然科学基金国家自然科学基金深圳市医疗卫生三名工程项目

8180400481904103SZZYSM 202111011

2024

世界中医药
世界中医药学会联合会

世界中医药

CSTPCDCHSSCD北大核心
影响因子:1.266
ISSN:1673-7202
年,卷(期):2024.19(5)
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