Objective:To explore the therapeutic effect and mechanism of Guiqi Huoxue Capsules(GQ)on cervical spondylotic ra-diculopathy(CSR)in rats.Methods:Spontaneous pain,thermal pain threshold,gait score,body surface microcirculatory status of forelimbs and neck,pathological structural and ultrastructural changes of the spinal cord,phosphorylation of p38 in the spinal cord,and serum serum interleukin-1 β(IL-1β),IL-6,and tumor necrosis factor-α(TNF-α)in CSR rats were observed.Results:High and medium-dose GQ could significantly increase the thermal pain threshold of CSR model rats after 14 days of intervention(P＜0.05),reduce their gait score and spontaneous pain score(P＜0.05,P＜0.01).All GQ doses groups could improve spinal cord inflammatory edema in CSR rats,significantly increase the number of Nissl-stained positive cells(P＜0.05),restore normal mor-phology of myelin sheaths and mitochondria.The medium-dose of GQ showed more significant effects.High and medium doses of GQ could significantly increase skin blood perfusion in the neck and forelimbs of CSR rats(P＜0.05),with a greater improvement in distal forelimb blood perfusion than the ibuprofen group(P＜0.01).Compared to the model group,the medium-dose GQ could reduce the phosphorylation ratio of p38 in the spinal cord of CSR rats.Conclusion:GQ can alleviate the degree of thermal hyperal-gesia and gait instability,improve the inflammatory pathological changes in the spinal cord,and restore the volume of body surface perfusion in the forelimbs and neck in CSR rats,and the medium-dose GQ is more advantageous in improving inflammatory injury in CSR rats.
关键词
归芪活血胶囊/神经根型颈椎病/疼痛/炎性损伤/体表微循环/活血通络/抗炎镇痛/p38
Key words
Guiqi Huoxue Capsules/Cervical spondylotic radiculopathy(CSR)/Pain/Inflammatory injury/Surface microcircula-tion/Activating blood and dredging collaterals/Anti-inflammatory and analgesic effects/p38
维普
万方数据