首页|归芪活血胶囊对神经根型颈椎病大鼠炎性损伤和微循环血流的影响

归芪活血胶囊对神经根型颈椎病大鼠炎性损伤和微循环血流的影响

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目的:探究归芪活血胶囊(GQ)对神经根型颈椎病(CSR)大鼠的治疗效应及机制.方法:观察CSR大鼠自发痛、热痛阈、步态评分、前肢和颈部体表微循环状态、脊髓病理结构及超微结构变化、脊髓p38磷酸化情况以及血清白细胞介素-1β(IL-1β)、IL-6以及肿瘤坏死因子-α(TNF-α).结果:GQ高、中剂量在干预第14天时可显著升高CSR模型大鼠的热痛阈(P＜0.05),降低其步态评分和自发痛评分(P＜0.05,P＜0.01);GQ各剂量均可改善CSR大鼠脊髓炎症水肿变化,显著增加尼氏(Nissl)染色阳性细胞数目(P＜0.05),恢复髓鞘和线粒体正常形态,且GQ中剂量效果较明显;GQ高、中剂量可显著升高CSR大鼠颈部和前肢皮肤血流灌注量(P＜0.05),对前肢远端血流灌注量的改善程度优于芬必得组(P＜0.01);与模型组比较,GQ中剂量可降低CSR大鼠脊髓p38磷酸化比率.结论:GQ可以缓解CSR大鼠热痛觉过敏和步态不稳的程度,改善脊髓炎症病理变化,恢复前肢和颈部体表血流灌注量,且GQ中剂量在改善CSR大鼠炎症损伤方面更有优势.
Effects of Guiqi Huoxue Capsules on Inflammatory Injury and Microcirculation Blood Flow in Rats with Cervical Spondylotic Radiculopathy
Objective:To explore the therapeutic effect and mechanism of Guiqi Huoxue Capsules(GQ)on cervical spondylotic ra-diculopathy(CSR)in rats.Methods:Spontaneous pain,thermal pain threshold,gait score,body surface microcirculatory status of forelimbs and neck,pathological structural and ultrastructural changes of the spinal cord,phosphorylation of p38 in the spinal cord,and serum serum interleukin-1 β(IL-1β),IL-6,and tumor necrosis factor-α(TNF-α)in CSR rats were observed.Results:High and medium-dose GQ could significantly increase the thermal pain threshold of CSR model rats after 14 days of intervention(P＜0.05),reduce their gait score and spontaneous pain score(P＜0.05,P＜0.01).All GQ doses groups could improve spinal cord inflammatory edema in CSR rats,significantly increase the number of Nissl-stained positive cells(P＜0.05),restore normal mor-phology of myelin sheaths and mitochondria.The medium-dose of GQ showed more significant effects.High and medium doses of GQ could significantly increase skin blood perfusion in the neck and forelimbs of CSR rats(P＜0.05),with a greater improvement in distal forelimb blood perfusion than the ibuprofen group(P＜0.01).Compared to the model group,the medium-dose GQ could reduce the phosphorylation ratio of p38 in the spinal cord of CSR rats.Conclusion:GQ can alleviate the degree of thermal hyperal-gesia and gait instability,improve the inflammatory pathological changes in the spinal cord,and restore the volume of body surface perfusion in the forelimbs and neck in CSR rats,and the medium-dose GQ is more advantageous in improving inflammatory injury in CSR rats.

Guiqi Huoxue CapsulesCervical spondylotic radiculopathy(CSR)PainInflammatory injurySurface microcircula-tionActivating blood and dredging collateralsAnti-inflammatory and analgesic effectsp38

嵇波、刘翼天、赵国桢、李博、方洋、石天宇、谢亚娜、张玲、郭亭廷、全烨、王一菲、吴乐

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北京中医药大学针灸推拿学院,北京,102401

首都医科大学北京中医医院,北京,100010

归芪活血胶囊 神经根型颈椎病 疼痛 炎性损伤 体表微循环 活血通络 抗炎镇痛 p38

"重大新药创制"科技重大专项北京中医药大学校级科研横向发展基金

2018ZX092010102030071720017

2024

10.3969/j.issn.1673-7202.2024.06.006

世界中医药
世界中医药学会联合会

世界中医药

CSTPCDCHSSCD北大核心
影响因子：1.266
ISSN：1673-7202
年,卷(期)：2024.19(6)
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