首页|药食同源中药治疗胃癌癌因性疲乏的用药规律

药食同源中药治疗胃癌癌因性疲乏的用药规律

扫码查看
目的:通过对文献的数据挖掘,初步探讨干预胃癌癌因性疲乏(CRF)的药食同源中药用药规律,并结合CRF中医病机及现代药理学研究进行分析.方法:检索国家知识基础设施数据库(CNKI)、中国学术期刊数据库(CSPD),筛选自建立数据库开始至2022年4月10日期间治疗胃癌CRF的临床文献,借助Microsoft Excel 2021及SPSS Modeler 26.0统计软件,以2018年卫健委公布的110种药食同源中药为参考,对收集文献所涉及的药食同源中药进行频数频率、性味归经、药效分类、关联规则分析、聚类分析,根据统计结果探讨药食同源中药干预胃癌CRF的用药规律.结果:收集文献中共有药食同源中药43味(占2018年卫健委所公布110种药食同源中药的39.09%),出现频数376次(占文献全部165味中药出现频数的49.41%);频数≥10次的药食同源中药共14味,按频数降序排列依次为黄芪、茯苓、当归、甘草、党参等;干预胃癌CRF的药食同源中药四气以平、温为主,五味以甘味药为主,归经以归脾经最多;发掘出21组治疗胃癌CRF的药食同源中药组合,支持度最高的组合是黄芪-当归;聚类分析提取获得3个核心聚类群.结论:药食同源中药干预胃癌CRF以健脾和胃为基本治则,辅以补肺滋肾,养血生津,理气燥湿为法,常用药食同源中药为黄芪、茯苓、当归等,可将这些药食同源中药用于胃癌CRF的治疗及保健食品的开发中.
Medication Patterns of Edible and Medicinal Chinese Herbs in Treatment of Gastric Cancer-related Fatigue
Objective:Through data mining of literature,this study preliminarily explores the patterns of used of edible and medici-nal Chinese herbs in interfering with Gastric Cancer-related Fatigue(CRF),combined with an analysis of TCM pathogenesis and modern pharmacological research for CRF.Methods:Chinese National Knowledge Infrastructure(CNKI)and Science Periodical Ci-tation Database(CSPD)were searched to retrieve clinical literatures on Gastric CRF up to April 10th,2022.Using Microsoft Excel 2021 and SPSS Modeler 26.0,and referencing 110 kinds of edible and medicinal Chinese herbs published by the Health Care Com-mission in 2018,frequency analysis,property and channel tropism,pharmacological classification,association rule analysis,and cluster analysis were performed on the herbs discussed in the collected literature.Based on the statistical results,medication pat-terns of edible and medicinal Chinese herbs intervening CRF were discussed.Results:There were 43 kinds of edible and medicinal Chinese herbs mentioned in the collected literature(39.09%of the 110 kinds of edible and medicinal Chinese herbs published by the Health Care Commission in 2018),with a frequency of occurrence was 376(49.41%of the occurrence frequency 165 tradition-al Chinese medicines from the collected literature).There were 14 kinds of edible and medicinal Chinese herbs with a frequency of≥10.Astragali Radix,Poria,Angelicae Sinensis Radix,Radix-et-Rhizoma-Glycyrrhizae,Radix-Codonopsis and etc were ranked in order of frequency from high to low.The herbs were mainly mild and warm in property,and sweet in flavor,with tropism at spleen.A total of 21 groups of edible and medicinal Chinese herb combinations for the treatment of gastric CRF were identified,with the-highest support for Astragali Radix and Angelicae Sinensis Radix.Three core clusters were identified by cluster analysis.Conclu-sion:The intervention in gastric cancer CRF with edible and medicinal Chinese herbs primarily focuses on strengthening the spleen and stomach,supplemented by nourishing lungs and kidneys,nourishing blood and producing fluids,and regulating qi and drying dampness.Common herbs include Astragali Radix,Poria and Angelicae Sinensis Radix,which can be used in the treatment of gas-tric CRF and in the development of health food.

Cancer-related FatigueConsumptive diseaseGastric CancerEdible and medicinal Chinese herbsData MiningMedication PatternsAstragali Radix

陈红瑶、杨仁义、郜文辉、曾普华

展开 >

湖南中医药大学,长沙,410208

湖南省中医药研究院附属医院,长沙,410006

癌因性疲乏 虚劳 胃癌 药食同源中药 数据挖掘 用药规律 黄芪

国家中医药局青年岐黄学者人才项目(第一批)湖南省重点研发计划湖南省中医药领军人才和学科带头人培养项目

国中医药人教发[2020]7号2021SK2006湘中医药[2022]4号

2024

世界中医药
世界中医药学会联合会

世界中医药

CSTPCDCHSSCD北大核心
影响因子:1.266
ISSN:1673-7202
年,卷(期):2024.19(6)
  • 22