Liparis nervosa is a plant of Liparis L.C.Rich(Orchidaceae),with a long medicinal history.It has the effects of clearing heat and detoxifying,cooling the blood and stopping bleeding,and relieving symptoms and pain.It is used for vomiting blood,he-moptysis,intestinal sub wind blood,blood avalanche and other diseases.The chemical composition of L.nervosa mainly includes al-kaloids,benzoates,phenanthrene,dihydrophenanthrenes and biphenanthrenes,which have antihyperuric,haemostatic and anticancer effects.This paper reviews and summarizes the chemical composition and pharmacological effects of L.nervosa.Based on the five principles of Chinese medicine quality markers(Q-Marker),this study predicts the Q-Marker of L.nervosa from various aspects such as traditional Chinese medicine properties of,conventional effects,and modern pharmacological effects of L.nervosa.It is pre-liminarily determined that alkaloids,phenanthrenes and flavonoids can be used as the main Q-markers of L.nervosa,which provides a basis for establishing and improving the quality control and evaluation methods of L.nervosa.