首页|基于真实世界观察针灸治疗轻中度产后抑郁障碍疗效的影响因素

基于真实世界观察针灸治疗轻中度产后抑郁障碍疗效的影响因素

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目的:基于真实世界观察针刺治疗轻中度产后抑郁障碍(PPD)疗效的影响因素.方法:前瞻性队列研究设计,通过国际针灸注册登记平台,收集真实世界中针灸治疗轻中度产后抑郁障碍的临床诊疗数据,共收集到来自6家医院的355例研究对象.将其以是否有效作为因变量,对年龄、病程、家人协助情况、孕期抑郁障碍史、抑郁程度、怀孕次数、流产情况、抑郁家族史、学历、针刺频次等变量进行单因素分析,筛选出与患者疗效相关的因素,再将其放入Cox回归模型进行多因素分析,探索影响针刺疗效的相关因素.结果:共纳入轻中度产后抑郁障碍受试者355例,其中329例评定为有效,有效率为92.7％.将经单因素分析后有统计学意义的因素纳入Cox回归模型中进行多因素分析,结果提示孕期抑郁障碍史、家人协助情况、针刺频次与针刺疗效具有相关性(均P＜0.05).结论:针刺治疗轻中度产后抑郁障碍有效,且针刺疗效与针刺频次、受试者家庭支持情况、孕期抑郁障碍病史相关(均P＜0.05),孕期无抑郁障碍史、家人协助情况良好、针刺频次较高者针刺疗效更佳,且起效时间更短.
Factors Influencing the Effect of Acupuncture Treatment of Mild-to-moderate Postpartum Depression Based on Real-world Study
Objective:To observe the influencing factors of acupuncture treatment effectiveness for mild-to-moderate postpartum depression(PPD)based on real-world data.Methods:A prospective cohort study design was employed.Clinical diagnosis and treatment data of acupuncture therapy for mild-to-moderate PPD in the real world were collected through the International Acupunc-ture Registration Platform.A total of 355 cases from six hospitals were included in the study.The effectiveness of acupuncture treat-ment was used as the dependent variable.Single-factor analysis was conducted on variables including age,duration of illness,family assistance status,history of antenatal depression,severity of depression,number of pregnancies,history of miscarriage,family history of depression,education level,and frequency of acupuncture sessions to identify factors related to patient efficacy.Subsequently,factors with statistical significance from the single-factor analysis were included in the Cox regression model for multifactor analysis to explore the relevant factors affecting acupuncture efficacy.Results:A total of 355 cases with mild-to-moderate PPD were includ-ed,among which 329 cases were assessed as effective,with an effectiveness rate of 92.7％.Factors with statistical significance from the single-factor analysis were included in the Cox regression model for multifactor analysis,indicating that a history of antenatal de-pression,family assistance status,and frequency of acupuncture sessions were correlated with acupuncture efficacy(all P＜0.05).Conclusion:Acupuncture treatment is effective for mild-to-moderate PPD,and acupuncture efficacy is correlated with the frequency of acupuncture sessions,family support for the cases,and history of antenatal depression(all P＜0.05).Cases without a history of antenatal depression,with good family support,and a higher frequency of acupuncture sessions showed better acupuncture efficacy and shorter onset time.

Postpartum depressionAcupuncture therapyReal-world studyFactors influencing efficacyHamilton Depression ScaleCox regressionMulticenter

徐健钦、罗文舒、杨卓欣、何丽云、海英、张辉、张春敏、何列涛、周鹏、于海波、王超、刘佳、黄杏贤、蒋娇娜、周玉梅、曹雪梅、马晓明、闫兵、杨福霞、丘江宁、王莉、袁金筠、朱燕娴、徐玉芹、刘凡

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广州中医药大学第四临床医学院,深圳,518033

深圳市中医院针灸科,深圳,518033

中国中医科学院临床基础医学研究所,北京,100700

辽宁中医药大学附属医院,沈阳,110033

中国医科大学附属盛京医院,沈阳,110136

河北省中医院,石家庄,050013

广西中医药大学第一附属医院,南宁,530022

深圳市宝安区中医院,深圳,518133

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产后抑郁障碍 针刺疗法 真实世界研究 疗效影响因素 汉密尔顿抑郁量表 Cox回归 多中心

国家重点研发计划广东省中医药局科研项目广东省医学科研项目

2017YFC170360420231283A2022116

2024

10.3969/j.issn.1673-7202.2024.07.004

世界中医药
世界中医药学会联合会

世界中医药

CSTPCDCHSSCD北大核心
影响因子：1.266
ISSN：1673-7202
年,卷(期)：2024.19(7)