世界中医药2024,Vol.19Issue(7) :931-935.DOI:10.3969/j.issn.1673-7202.2024.07.004

基于真实世界观察针灸治疗轻中度产后抑郁障碍疗效的影响因素

Factors Influencing the Effect of Acupuncture Treatment of Mild-to-moderate Postpartum Depression Based on Real-world Study

徐健钦 罗文舒 杨卓欣 何丽云 海英 张辉 张春敏 何列涛 周鹏 于海波 王超 刘佳 黄杏贤 蒋娇娜 周玉梅 曹雪梅 马晓明 闫兵 杨福霞 丘江宁 王莉 袁金筠 朱燕娴 徐玉芹 刘凡
世界中医药2024,Vol.19Issue(7) :931-935.DOI:10.3969/j.issn.1673-7202.2024.07.004

基于真实世界观察针灸治疗轻中度产后抑郁障碍疗效的影响因素

Factors Influencing the Effect of Acupuncture Treatment of Mild-to-moderate Postpartum Depression Based on Real-world Study

徐健钦 1罗文舒 2杨卓欣 2何丽云 3海英 4张辉 5张春敏 6何列涛 7周鹏 8于海波 2王超 3刘佳 3黄杏贤 2蒋娇娜 2周玉梅 2曹雪梅 2马晓明 2闫兵 2杨福霞 2丘江宁 2王莉 1袁金筠 1朱燕娴 1徐玉芹 1刘凡2
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作者信息

  • 1. 广州中医药大学第四临床医学院,深圳,518033
  • 2. 深圳市中医院针灸科,深圳,518033
  • 3. 中国中医科学院临床基础医学研究所,北京,100700
  • 4. 辽宁中医药大学附属医院,沈阳,110033
  • 5. 中国医科大学附属盛京医院,沈阳,110136
  • 6. 河北省中医院,石家庄,050013
  • 7. 广西中医药大学第一附属医院,南宁,530022
  • 8. 深圳市宝安区中医院,深圳,518133
  • 折叠

摘要

目的:基于真实世界观察针刺治疗轻中度产后抑郁障碍(PPD)疗效的影响因素.方法:前瞻性队列研究设计,通过国际针灸注册登记平台,收集真实世界中针灸治疗轻中度产后抑郁障碍的临床诊疗数据,共收集到来自6家医院的355例研究对象.将其以是否有效作为因变量,对年龄、病程、家人协助情况、孕期抑郁障碍史、抑郁程度、怀孕次数、流产情况、抑郁家族史、学历、针刺频次等变量进行单因素分析,筛选出与患者疗效相关的因素,再将其放入Cox回归模型进行多因素分析,探索影响针刺疗效的相关因素.结果:共纳入轻中度产后抑郁障碍受试者355例,其中329例评定为有效,有效率为92.7%.将经单因素分析后有统计学意义的因素纳入Cox回归模型中进行多因素分析,结果提示孕期抑郁障碍史、家人协助情况、针刺频次与针刺疗效具有相关性(均P<0.05).结论:针刺治疗轻中度产后抑郁障碍有效,且针刺疗效与针刺频次、受试者家庭支持情况、孕期抑郁障碍病史相关(均P<0.05),孕期无抑郁障碍史、家人协助情况良好、针刺频次较高者针刺疗效更佳,且起效时间更短.

Abstract

Objective:To observe the influencing factors of acupuncture treatment effectiveness for mild-to-moderate postpartum depression(PPD)based on real-world data.Methods:A prospective cohort study design was employed.Clinical diagnosis and treatment data of acupuncture therapy for mild-to-moderate PPD in the real world were collected through the International Acupunc-ture Registration Platform.A total of 355 cases from six hospitals were included in the study.The effectiveness of acupuncture treat-ment was used as the dependent variable.Single-factor analysis was conducted on variables including age,duration of illness,family assistance status,history of antenatal depression,severity of depression,number of pregnancies,history of miscarriage,family history of depression,education level,and frequency of acupuncture sessions to identify factors related to patient efficacy.Subsequently,factors with statistical significance from the single-factor analysis were included in the Cox regression model for multifactor analysis to explore the relevant factors affecting acupuncture efficacy.Results:A total of 355 cases with mild-to-moderate PPD were includ-ed,among which 329 cases were assessed as effective,with an effectiveness rate of 92.7%.Factors with statistical significance from the single-factor analysis were included in the Cox regression model for multifactor analysis,indicating that a history of antenatal de-pression,family assistance status,and frequency of acupuncture sessions were correlated with acupuncture efficacy(all P<0.05).Conclusion:Acupuncture treatment is effective for mild-to-moderate PPD,and acupuncture efficacy is correlated with the frequency of acupuncture sessions,family support for the cases,and history of antenatal depression(all P<0.05).Cases without a history of antenatal depression,with good family support,and a higher frequency of acupuncture sessions showed better acupuncture efficacy and shorter onset time.

关键词

产后抑郁障碍/针刺疗法/真实世界研究/疗效影响因素/汉密尔顿抑郁量表/Cox回归/多中心

Key words

Postpartum depression/Acupuncture therapy/Real-world study/Factors influencing efficacy/Hamilton Depression Scale/Cox regression/Multicenter

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基金项目

国家重点研发计划(2017YFC1703604)

广东省中医药局科研项目(20231283)

广东省医学科研项目(A2022116)

出版年

2024
世界中医药
世界中医药学会联合会

世界中医药

CSTPCDCHSSCD北大核心
影响因子:1.266
ISSN:1673-7202
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