首页|中药通过细胞外信号调节激酶信号通路调控胃癌的研究进展

中药通过细胞外信号调节激酶信号通路调控胃癌的研究进展

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胃癌在我国发病率和死亡率较高,存在发现晚、5年生存率低的特点,手术切除仍然是临床治疗的主要方法.大鼠肉瘤蛋白(Ras)/迅速加速性纤维肉瘤蛋白(Raf)/丝裂原活化的细胞外信号调节激酶(MEK)/细胞外信号调节激酶(ERK)信号通路在调控细胞增殖、转移、凋亡等方面具有非常重要的作用,与胃癌的发生与发展密切相关.近年来,很多学者探索调控Ras/Raf/MEK/ERK信号通路治疗胃癌的作用机制,在信号转导机制研究、靶向抑制剂筛选、中医药治疗等方面取得大量成果,实验验证在胃癌的治疗中干预其信号传递具有良好的效果和应用前景.
Research Progress in the Regulation of Gastric Cancer by Traditional Chinese Medicine Through Extracellular Signal-regulated Kinase Signaling Pathway
The incidence and mortality of gastric cancer in China are high,with the characteristics of late detection and low five-year survival rate.Surgical resection is still the main method of clinical treatment.Ras/Raf/MEK/ERK signaling pathway plays a very important role in regulating cell proliferation,metastasis and apoptosis,which is closely related to the development and progres-sion of gastric cancer.In recent years,many scholars have explored the mechanism of regulating Ras/Raf/MEK/ERK pathway in the treatment of gastric cancer,and have made a lot of achievements in signal transduction mechanism research,targeted inhibitor screening,traditional Chinese medicine treatment and other aspects.Experimental validations have shown that mediating Ras/Raf/MEK/ERK pathway signaling has good effects and application prospects in the treatment of gastric cancer.

Ras/Raf/MEK/ERK signaling pathwayGastric CancerGenetic MutationsInhibitorsTargeted TherapyTradi-tional Chinese MedicineResearch ProgressMechanism of Action

赵颖异、吕星、谭雅兰、韩永光

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河南中医药大学药学院,郑州,450046

大鼠肉瘤蛋白/迅速加速性纤维肉瘤蛋白/丝裂原活化的细胞外信号调节激酶/细胞外信号调节激酶(Ras/Raf/MEK/ERK)信号通路 胃癌 基因突变 抑制剂 靶向治疗 中药 研究进展 作用机制

国家重点研发计划河南省高等学校青年骨干教师培养计划河南张仲景方药与免疫调节重点实验室开放基金河南省大学生创新创业训练计划河南中医药大学研究生科研创新能力提升计划(2021)

2019YFC17088022020GGJS111KFKT202002S2021104710302021KYCX053

2024

10.3969/j.issn.1673-7202.2024.07.024

世界中医药
世界中医药学会联合会

世界中医药

CSTPCDCHSSCD北大核心
影响因子：1.266
ISSN：1673-7202
年,卷(期)：2024.19(7)