首页|基于肿瘤外泌体探讨中医药防治大肠癌肝转移机制

基于肿瘤外泌体探讨中医药防治大肠癌肝转移机制

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肝脏作为结直肠癌常见的远处转移靶器官,其发生转移受到人体自身免疫力和肿瘤微环境等多因素调控的影响.肝转移是结直肠癌晚期患者死亡的主要原因.外泌体是直径为30～150 nm的细胞外囊泡体,结直肠癌来源的外泌体含有的miRNA与癌基因参与肿瘤的复发、转移.中医认为结直肠癌肝转移(CRLM)的原因不外乎"正虚"与"邪实".中医药具有整体性、多成分、多靶点的特点,可通过调节外泌体调控细胞间通信并影响肿瘤微环境,防治肿瘤的复发、转移.一方面通过"扶正健脾固本"提高患者免疫力,改善肿瘤抑制微环境;另一方面通过"调气祛瘀解毒"改善肿瘤炎症微环境,使癌毒无法存活.
Mechanism of Traditional Chinese Medicine in the Prevention and Treatment of Colorectal Cancer Liver Metastasis Based on Tumor Exosomes
As a common target organ for distant metastasis in colorectal cancer,metastasis to the liver is influenced by various fac-tors such as the immune system of the body and the tumor microenvironment.Liver metastasis is a major cause of death in patients with advanced colorectal cancer.Exosomes are extracellular vesicles with a diameter of 30 to 150 nm.Exosomes derived from color-ectal cancer contain miRNAs and oncogenes that participate in tumor recurrence and metastasis.Traditional Chinese medicine(TCM)believes that the causes of colorectal cancer liver metastasis(CRLM)are mainly related to"deficiency of vital qi"and"excess of pathogenic qi".TCM features holistic treatment,multiple components,and multiple targets,which can regulate intercel-lular communication through exosomes and affect the tumor microenvironment to prevent tumor recurrence and metastasis.On one hand,by"strengthening the vital qi,invigorating the spleen,and consolidating the foundation",TCM can enhance the patient's im-mune system and improve the tumor-suppressive microenvironment.On the other hand,by"regulating qi,eliminating blood stasis,and removing toxin",TCM can improve the tumor's inflammatory microenvironment,making it inhospitable for cancerous growth.

Colorectal cancerExosomeTumor microenvironmentLiver metastasisTraditional Chinese medicineMechanismDeficiency of vital qiExcess of pathogenic qi

王成磊、张广辉、陈雪、杨冰炜、李卫东

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陕西中医药大学,咸阳,712046

中国中医科学院广安门医院,北京,100053

结直肠癌 外泌体 肿瘤微环境 肝转移 中医药 作用机制 正虚 邪实

国家自然科学基金面上项目中国中医科学院科技创新工程重大攻关项目北京市自然科学基金

82174464CI2021A018067212189

2024

10.3969/j.issn.1673-7202.2024.07.026

世界中医药
世界中医药学会联合会

世界中医药

CSTPCDCHSSCD北大核心
影响因子：1.266
ISSN：1673-7202
年,卷(期)：2024.19(7)