Effects of Ethyl Acetate Extract of Taxus Chinensis Fruit on Phenotype and Inflammatory Cytokines in Rats with Depression
Objective:To investigate the effects of ethyl acetate extract of Taxus chinensis fruit on the depression model of rats and its possible mechanism.Methods:Twenty female SD rats were randomly divided into the normal group,model group,Taxus chinen-sis fruit group,and fluoxetine group,with five rats in each group.Except for the normal group,the chronic unpredictable mild stress(CUMS)method was used to prepare the depression model in other groups for four weeks.After modeling,the Taxus chinensis fruit group was given 200 mg/(kg·d)of ethyl acetate extract of Taxus chinensis fruit,and the normal group and the model group were given an equal volume of normal saline by intragastric administration for four weeks.After the modeling,the normal group and the model group were subjected to the sugar water experiment and the field test.After the administration,the rats in each group were subjected to the sugar water experiment and the field test,and the serum content of interleukin 1β(IL-1β),IL-6,and IL-18 was de-tected.Results:Compared with that in the normal group after the modeling,the sugar water consumption of rats in the model group was significantly decreased(P＜0.01),and the activity was significantly decreased(P＜0.01).After the experiment,compared with those in the model group,the sugar water consumption and activity of rats in the Taxus chinensis fruit group and the fluoxetine group were significantly increased(P＜0.01).Compared with that in the normal group,the serum content of IL-1β,IL-6,and IL-18 in the model group was significantly increased(P＜0.05,P＜0.01).Compared with that in the model group,the serum content of IL-1β,IL-6,and IL-18 in the Taxus chinensis fruit group and the fluoxetine group was significantly decreased(P＜0.05,P＜0.01).Conclusion:The ethyl acetate extract of Taxus chinensis fruit has both antidepressant and anti-inflammatory effects,which may alleviate depression-like behavior in rats by reducing inflammatory response.
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