A Network Meta-analysis of the Efficacy of Nine Commonly Used Classical Prescriptions in Treating Bronchial Asthma in Adults
Objective:To evaluate the efficacy of nine classical prescriptions in treating bronchial asthma in adults with different syndromes by a network meta-analysis and provide a therapeutic basis for the clinical treatment of bronchial asthma.Methods:The randomized controlled trials(RCTs)of nine classical prescriptions(Yupingfeng Powder,Sangbaipi Decoction,Maxing Shigan De-coction,Suzi Jiangqi Decoction,Sanzi Yangqin Decoction,Xiaoqinglong Decoction,Dingchuan Decoction,Jinshui Liujun Decoction,and Shegan Mahuang Decoction)for treating bronchial asthma in adults were searched against the China National Knowledge Infra-structure(CNKI),China Science Periodical Database(CSPD),and Chinese Citation Database(CCD)with the time interval from inception to December 20,2021.The network meta-analysis was conducted for the included articles in Stata 16.0.Results:A total of 41 articles were included in this study.The five best treatment regimens in improving the clinical response rate were Shegan Mahuang Decoction+Western Medicine＞Yupingfeng Powder+Western Medicine＞Jinshui Liujun Decoction+Western Medicine＞Dingchuan Decoction+Western Medicine＞Maxing Shigan Decoction+Western Medicine.In terms of improving the forced expiratory volume in the 1st second(FEV1％),the best 5 treatment regimens were Yupingfeng Powder+Western Medicine＞Shegan Mahuang Decoction+Western Medicine＞Dingchuan Decoction+Western Medicine＞Xiaoqinglong Decoction+Western Medicine＞Suzi Jiangqi Decoction+Western Medicine.The cases of adverse reactions in the observation group were all fewer than those in the control group.Conclusion:All the nine commonly used classical prescriptions combined with Western medicine could increase the clinical response rate and FEV1％and reduce the cases of adverse reactions compared with Western medicine alone.Due to limitations in the quality of the included articles,more rigorously designed RCTs are needed to verify the conclusion.
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