首页|大鼠急性血瘀证模型造模方法的网状Meta分析

大鼠急性血瘀证模型造模方法的网状Meta分析

扫码查看
原文链接
  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
目的:采用网状Meta分析评价不同急性血瘀证模型造模方法的效果,为中医实验研究急性血瘀证动物模型的制备提供循证依据.方法:检索中国期刊全文数据库(CNKI)、中国学术期刊数据库(CSPD)、中文科技期刊数据库(CCD)中有关急性血瘀证模型的建模方法,应用Stata软件进行网状Meta分析.结果:最终纳入32项研究,共纳入9种造模方案.各项指标最优前3位概率排序分别为:1)全血黏度:1 S-1切变率右旋糖酐＞高脂＞氢化可的松+肾上腺素,10 S-1切变率冰水浴＞肾上腺素＞高脂+力竭游泳,30 S-1切变率多因素刺激＞右旋糖酐＞肾上腺素,60 S-1切变率多因素刺激＞右旋糖酐＞肾上腺素,150 S-1切变率肾上腺素＞冰水浴＞高脂+力竭游泳,200 S-1切变率右旋糖酐＞氢化可的松+肾上腺素＞角叉莱胶+内毒素;2)血浆黏度:右旋糖酐＞多因素刺激＞肾上腺素;3)红细胞聚集指数:冰水浴＞多因素刺激＞高脂+力竭游泳.受纳入研究质量和数量的限制,所得结论仍待进一步验证.结论:右旋糖酐、冰水浴、多因素刺激、肾上腺素造模效果更显著.
Network Meta-Analysis of Modeling Methods for Rats with Acute Blood Stasis Syndrome
Objective:To evaluate the effect of different modeling methods for acute blood stasis syndrome by network meta-analy-sis and provide an evidence-based basis for the preparation of an animal model with acute blood stasis syndrome in research of tra-ditional Chinese medicine(TCM).Methods:The modeling methods for acute blood stasis syndrome were searched from Databases of China National Knowledge Infrastructure(CNKI),China Science Periodical Database(CSPD),and Chinese Citation Database(CCD).The network meta-analysis was carried out by Stata software.Results:A total of 32 pieces of literature and nine modeling schemes were finally included.The best first three probability indexes were ranked as follows:1)whole blood viscosity:1 S-1 shear rate dextran＞high fat＞hydrocortisone+adrenaline,10 S-1 shear rate ice water bath＞adrenaline＞high-fat feeding+exhaustive swimming,30 S-1 shear rate multifactor stimulation＞dextran＞adrenaline,60 S-1 shear rate multifactor stimulation＞dextran＞adrenaline,150 S-1 shear rate adrenaline＞ice water bath＞high-fat feeding+exhaustive swimming,200 S-1 shear rate dextran＞hydrocortisone+adrenaline＞carrageenan+endotoxin;2)plasma viscosity:dextran＞multifactor stimulation＞adrenaline;3)e-rythrocyte aggregation index:ice water bath＞multifactor stimulation＞high-fat feeding+exhaustive swimming.Limited by the quali-ty and quantity of the included studies,the conclusions still need to be further verified.Conclusion:dextran,ice water bath,multi-factor stimulation,and adrenaline are more effective in modeling.

Acute blood stasis syndromeAnimal modelModeling methodsRatsAssessment of modelExperimental methodsNetwork meta-analysisSystematic review

宋慧平、岳傲春、李泽坤、韩伟、李琴

展开 >

山东中医药大学第一临床学院,济南,250199

深圳大学总医院急诊科,深圳,518071

青岛大学医学部,青岛,266075

青岛大学附属烟台毓璜顶医院中西医结合科,烟台,264099

展开 >

急性血瘀证 动物模型 造模方法 大鼠 模型评价 实验方法 网状Meta分析 系统评价

国家自然科学基金项目国家自然科学基金项目山东省自然科学基金项目山东省自然科学基金项目山东省重点研发项目深圳市医疗卫生三名工程项目

8207146581571283ZR2020MH154ZR2016HL212018GSF118215SZSM201911007

2024

10.3969/j.issn.1673-7202.2024.08.007

世界中医药
世界中医药学会联合会

世界中医药

CSTPCDCHSSCD北大核心
影响因子：1.266
ISSN：1673-7202
年,卷(期)：2024.19(8)