针刺调控缺氧诱导因子-1α信号通路改善缺血性脑血管病的作用机制
Mechanism of Acupuncture Regulating HIF-1α Signaling Pathway to Ameliorate Ischemic Cerebrovascular Disease
姜海伦 1朱巍明 1张超 2孟祥刚 2李姗姗 3孟智宏2
作者信息
- 1. 天津中医药大学第一附属医院,天津,300381;天津中医药大学,天津,301617;国家中医针灸临床医学研究中心,北京,102206
- 2. 天津中医药大学第一附属医院,天津,300381;国家中医针灸临床医学研究中心,北京,102206
- 3. 天津中医药大学,天津,301617
- 折叠
摘要
缺血性脑血管疾病是常见的神经系统疾病之一,具有高致残率,高死亡率的特点,加剧了世界范围内的医疗卫生经济负担.缺氧诱导因子-1α(HIF-1α)是低氧响应的关键因子,在缺血性脑血管病发生和发展过程中发挥重要作用,而针刺在缺血性脑血管病的治疗中同样显示出显著优势.针刺调控HIF-1α信号通路可能是针刺产生疗效的关键机制之一.既往研究初步表明针刺对HIF-1α的调控作用可能不仅与疾病的损伤类型相关,还可能与HIF-1α的表达的时效效应以及针刺的介入时机相关.
Abstract
Ischemic cerebrovascular disease is one of the common nervous system diseases with a high disability rate and high mor-tality,which has aggravated the economic burden of health worldwide.Hypoxia-inducible factor(HIF-1α)is a key factor in re-sponse to hypoxia,playing an important role in the occurrence and development of ischemic cerebrovascular disease.Acupuncture has demonstrated significant advantages in the treatment of this disease.Acupuncture may regulate the HIF-1α signaling pathway to exert the therapeutic effect,which may be the main mechanism.Studies have shown that the regulatory effect of acupuncture on HIF-1α may be related to not only the type of injury but also the time effect of HIF-1α expression and the timing of acupuncture in-tervention.
关键词
缺氧诱导因子-1α/缺血性脑血管疾病/针刺/脑梗死/缺血再灌注/血管再生/神经保护/综述Key words
Hypoxia-inducible factor-1α/Ischemic cerebrovascular disease/Acupuncture/Cerebral infarction/Ischemia reperfu-sion/Revascularization/Neuroprotection/Review引用本文复制引用
基金项目
国家自然科学基金项目(8220153095)
出版年
2024
国家科技期刊平台
NSTL
万方数据