黄葵胶囊治疗慢性肾脏病的研究进展
Huangkui Capsules in Treatment of Chronic Kidney Disease:A Review
于小芸 1薛雪峰 2李锋 3赵静静1
作者信息
- 1. 庆阳市中医医院,庆阳,745099
- 2. 西安中医脑病医院,西安,710032
- 3. 空军军医大学西京医院,西安,710032
- 折叠
摘要
慢性肾脏病是一种慢性肾功能不全综合征,其病理特征主要为肾单位的丢失、炎症反应、肌成纤维细胞活化及细胞外基质沉积.慢性肾脏病发病率较高,全球10％～13％的人口罹患慢性肾病,是危害全球人类健康的公共卫生问题.黄葵胶囊为国家药监局批准的一种中成药,由黄蜀葵花植物药组成,安全性较高,临床上常用于治疗肾脏相关疾病.研究表明,黄葵胶囊可通过改善机体免疫功能、抑制炎症反应、缓解肾纤维化和肾小管上皮细胞损伤而发挥慢性肾脏病治疗作用.然而目前仍缺乏黄葵胶囊改善慢性肾脏病的临床数据以及药效物质基础的挖掘研究.
Abstract
Chronic kidney disease(CKD)is a chronic renal insufficiency syndrome characterized by the loss of nephrons,inflam-matory responses,activation of myofibroblasts,and extracellular matrix deposition.CKD has a high prevalence,affecting approxi-mately 10％to 13％of the global population,making it a significant public health issue worldwide.Huangkui Capsules,a Chinese patent medicine approved by the National Medical Products Administration,are composed of herbal drug Abelmoschi Corolla and are known for their high safety profile.Clinically,they are commonly used to treat kidney-related diseases.Studies have shown that Huangkui Capsules can treat CKD by improving immune function,inhibiting inflammatory responses,alleviating renal fibrosis,and reducing damage to renal tubular epithelial cells.However,there is still a lack of clinical data on the efficacy of Huangkui Capsules in improving CKD and a need for further research into their pharmacological mechanisms.
关键词
黄葵胶囊/黄蜀葵花/慢性肾脏病/糖尿病肾病/慢性肾小球肾炎/药效物质基础评价/炎症反应Key words
Huangkui Capsules/Abelmoschi Corolla/Chronic kidney disease/Diabetic nephropathy/Chronic glomerulonephri-tis/Evaluation of the material basis of efficacy/Inflammatory response引用本文复制引用
基金项目
国家自然科学基金项目(81702213)
陕西省名中医传承工作室建设项目(2019029)
陕西省中医药管理局重点研究室项目(陕中医药函[2019]94号)
出版年
2024
国家科技期刊平台
NSTL
万方数据